Ox40 Antibody (2Q1716): sc-71768

Ox40 Antibody (2Q1716) is a rat monoclonal IgG1 antibody that detects the Ox40 cell surface antigen of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Ox40 (2Q1716) antibody is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. Ox40, also known as CD134 or Ox40R, is a crucial member of the tumor necrosis factor receptor (TNFR) family, playing a significant role in the immune response. Ox40 is primarily located on the surface of activated CD4+ T lymphocytes, where Ox40 is essential for the coordination of T cell selection, migration, and cytokine differentiation, particularly in T helper (Th)1 and Th2 cells. The interaction between Ox40 and Ox40L, predominantly expressed on activated B cells, delivers a potent costimulatory signal that enhances T cell activation and promotes optimal CD4+ T cell responses both in vivo and in vitro. This signaling pathway regulates immune responses, influencing the development of T cell-dependent humoral responses and contributing to immune homeostasis. Members of the TNFR superfamily, including Ox40, are critically involved in regulating infections, inflammation, autoimmune diseases, and tissue homeostasis, underscoring Ox40′s importance in both health and disease.

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Ox40 Antibody (2Q1716) References:

1. Roles of OX40 in the pathogenesis and the control of diseases.  |  Hori, T. 2006. Int J Hematol. 83: 17-22. PMID: 16443547
2. Targeting OX40 and OX40L for the treatment of autoimmunity and cancer.  |  Redmond, WL. and Weinberg, AD. 2007. Crit Rev Immunol. 27: 415-36. PMID: 18197805
3. OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology.  |  Ishii, N., et al. 2010. Adv Immunol. 105: 63-98. PMID: 20510730
4. OX40/OX40 ligand interactions in T-cell regulation and asthma.  |  Kaur, D. and Brightling, C. 2012. Chest. 141: 494-499. PMID: 22315115
5. OX40 promotes obesity-induced adipose inflammation and insulin resistance.  |  Liu, B., et al. 2017. Cell Mol Life Sci. 74: 3827-3840. PMID: 28612217
6. The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy.  |  Buchan, SL., et al. 2018. Blood. 131: 39-48. PMID: 29118006
7. OX40 expression in neutrophils promotes hepatic ischemia/reperfusion injury.  |  Jin, H., et al. 2019. JCI Insight. 4: PMID: 31672934
8. OX40 as a novel target for the reversal of immune escape in colorectal cancer.  |  Yan, LH., et al. 2021. Am J Transl Res. 13: 923-934. PMID: 33841630
9. OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.  |  van der Sluis, TC., et al. 2023. Cell Rep Med. 4: 100939. PMID: 36796366
10. Challenges and opportunities in the development of combination immunotherapy with OX40 agonists.  |  Redmond, WL. 2023. Expert Opin Biol Ther. 23: 901-912. PMID: 37587644

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ox40 Antibody (2Q1716) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Ox40 Antibody (2Q1716) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ox40 Antibody (2Q1716) Specifications

Alternate Product Name: Ox40

Product Clone Name: 2Q1716

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Ox40

Epitope Species: mouse

Product Reactivity/Detection: Ox40 cell surface antigen

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Ox40 Antibody (2Q1716): FITC: Fluoroscein, PE: Phycoerythrin

The preferred Ox40 antibody is Ox40 Antibody (BER-Act35): sc-20073.