OX2 Antibody (3H1976): sc-71759

OX2 Antibody (3H1976) is a mouse monoclonal IgG1 antibody that detects OX2 in human samples through flow cytometry (FCM). OX2, also known as CD200, is a critical member of the immunoglobulin superfamily (IgSF) and functions as a cell surface glycoprotein composed of 248 amino acids. OX2 plays a vital role in modulating immune responses by interacting with OX2R, which is predominantly expressed in lymphoid and neuronal tissues. The interaction between OX2 and OX2R helps regulate macrophage activity, thereby suppressing excessive inflammatory responses that can lead to tissue damage. OX2R is characterized by a high degree of N-linked glycosylation, accounting for up to 70% of molecular weight, which is essential for stability and function. The cytoplasmic domain of OX2R contains NPXY motifs that facilitate interactions with specific binding domains, further underscoring the importance of these proteins in maintaining immune homeostasis. Anti-OX2 antibody (3H1976) is an invaluable tool for researchers investigating the intricate mechanisms of immune regulation and the potential therapeutic implications of targeting the OX2/OX2R pathway.

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OX2 Antibody (3H1976) References:

1. Fgl2 prothrombinase expression in mouse trophoblast and decidua triggers abortion but may be countered by OX-2.  |  Clark, DA., et al. 2001. Mol Hum Reprod. 7: 185-94. PMID: 11160845
2. Placental trophoblast from successful human pregnancies expresses the tolerance signaling molecule, CD200 (OX-2).  |  Clark, DA., et al. 2003. Am J Reprod Immunol. 50: 187-95. PMID: 14629022
3. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.  |  Malherbe, P., et al. 2009. Br J Pharmacol. 156: 1326-41. PMID: 19751316
4. Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA).  |  Malherbe, P., et al. 2010. Mol Pharmacol. 78: 81-93. PMID: 20404073
5. CD200 (OX-2 membrane glycoprotein) expression in b cell-derived neoplasms.  |  Dorfman, DM. and Shahsafaei, A. 2010. Am J Clin Pathol. 134: 726-33. PMID: 20959655
6. CD200 (OX-2 membrane glycoprotein) is expressed by follicular T helper cells and in angioimmunoblastic T-cell lymphoma.  |  Dorfman, DM. and Shahsafaei, A. 2011. Am J Surg Pathol. 35: 76-83. PMID: 21164290
7. Suppression of antigen-specific T cell responses by the Kaposi's sarcoma-associated herpesvirus viral OX2 protein and its cellular orthologue, CD200.  |  Misstear, K., et al. 2012. J Virol. 86: 6246-57. PMID: 22491458
8. OX2 receptors mediate the inhibitory effects of orexin-A on potassium chloride-induced increases in intracellular calcium ion levels in neurons derived from rat dorsal root ganglion in a chronic pain model.  |  Yamaguchi, M., et al. 2020. Neuropsychopharmacol Rep. 40: 30-38. PMID: 31845549
9. The gene for MRC OX-2 membrane glycoprotein is localized on human chromosome 3.  |  McCaughan, GW., et al. 1987. Immunogenetics. 25: 133-5. PMID: 3817906
10. Reported sequence homology between Alzheimer amyloid770 and the MRC OX-2 antigen does not predict function.  |  Richards, SJ., et al. 1995. Brain Res Bull. 38: 305-6. PMID: 7496825

The preferred OX2 antibody is OX2 Antibody (OX90): sc-53100.