OX2 Antibody (3H1963): sc-71763
- OX2 Antibody (3H1963) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against CD200 of mouse origin
- recommended for detection of OX2 a cell surface antigen of mouse origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for OX2 Antibody (3H1963). This work is in progress.
QUICK LINKS
OX2 Antibody (3H1963) is a rat monoclonal IgG2a antibody that detects OX2 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). OX2, also known as CD200, is a critical member of the immunoglobulin superfamily, functioning as a cell surface glycoprotein that plays a significant role in modulating immune responses. This 248-residue protein is predominantly expressed in lymphoid cells, neurons, and endothelial tissues, where OX2 interacts with OX2R. OX2 (3H1963) monoclonal antibody enables research into OX2′s ability to engage with OX2R, which is primarily located on the surface of myeloid cells, including macrophages. This interaction helps suppress excessive inflammatory responses, thereby protecting tissues from damage during immune reactions. Notably, the cytoplasmic domain of OX2R contains NPXY motifs that facilitate binding to specific proteins, further underscoring OX2′s role in regulating immune signaling pathways. Anti-OX2 antibody (3H1963) is an invaluable tool for researchers investigating the intricate mechanisms of immune modulation and inflammation in mouse models.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OX2 Antibody (3H1963) References:
- CD200 and membrane protein interactions in the control of myeloid cells. | Barclay, AN., et al. 2002. Trends Immunol. 23: 285-90. PMID: 12072366
- CD200 and its receptors as targets for immunoregulation. | Gorczynski, RM. 2005. Curr Opin Investig Drugs. 6: 483-8. PMID: 15912961
- Positive predictive value of CD200 positivity in the differential diagnosis of chronic lymphocytic leukemia. | Sorigue, M., et al. 2020. Cytometry B Clin Cytom. 98: 441-448. PMID: 31692239
- Estrogen-regulated CD200 inhibits macrophage phagocytosis in endometriosis. | Weng, LC., et al. 2020. J Reprod Immunol. 138: 103090. PMID: 32014721
- The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke. | Sun, H., et al. 2020. J Neuroinflammation. 17: 171. PMID: 32473633
- Clinical Importance of CD200 Expression in Colorectal Liver Metastasis. | Matsuo, Y., et al. 2021. Ann Surg Oncol. 28: 5362-5372. PMID: 33393050
- CD200 -dependent and -independent immune-modulatory functions of neural stem cells. | Arad, T., et al. 2021. Stem Cell Res. 56: 102559. PMID: 34634761
- Immunohistochemical Expression of CD200 in Renal Cell Carcinoma. | El Hanbuli, HM., et al. 2021. J Microsc Ultrastruct. 9: 136-140. PMID: 34729355
- Brain endothelial CD200 signaling protects brain against ischemic damage. | Misrani, A., et al. 2024. Brain Res Bull. 207: 110864. PMID: 38157992
- Cortical CD200-CD200R and CD47-SIRPα expression is associated with multiple sclerosis pathology. | van den Bosch, AMR., et al. 2024. Brain Commun. 6: fcae264. PMID: 39175944
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OX2 Antibody (3H1963) | sc-71763 | 200 µg/ml | $322.00 | |||
OX2 Antibody (3H1963) FITC | sc-71763 FITC | 200 µg/ml | $336.00 | |||
OX2 Antibody (3H1963) PE | sc-71763 PE | 200 µg/ml | $349.00 |