OX2 Antibody (2Q1778): sc-71761
- OX2 Antibody (2Q1778) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against full length CD200 of rat origin
- recommended for detection of a monomorphic determinant of OX2 of mouse and rat origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for OX2 Antibody (2Q1778). This work is in progress.
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OX2 Antibody (2Q1778) is a mouse monoclonal IgG1 antibody that detects OX2 in mouse and rat samples through applications such as immunofluorescence (IF) and flow cytometry (FCM). OX2, also known as CD200, is a critical member of the immunoglobulin superfamily, functioning as a cell surface glycoprotein that plays a significant role in modulating immune responses. This 248-residue protein is predominantly expressed in lymphoid cells, neurons, and endothelial tissues, where OX2 interacts with OX2R. The interaction between OX2 and OX2R is essential for maintaining immune homeostasis, as OX2 helps to suppress excessive macrophage activation and limit inflammatory damage in tissues. Notably, the cytoplasmic domain of OX2R contains NPXY motifs that facilitate binding to phosphotyrosine-binding (PTB) domains, further underscoring the importance of this signaling pathway in regulating immune responses. OX2 (2Q1778) antibody serves as an invaluable tool for researchers investigating the intricate mechanisms of immune regulation and the role of OX2 in various physiological and pathological contexts.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OX2 Antibody (2Q1778) References:
- CD200 Expression in Neuroendocrine Neoplasms. | Love, JE., et al. 2017. Am J Clin Pathol. 148: 236-242. PMID: 28821198
- Role of the CD200-CD200R Axis During Homeostasis and Neuroinflammation. | Manich, G., et al. 2019. Neuroscience. 405: 118-136. PMID: 30367946
- CD200-CD200R Pathway in the Regulation of Tumor Immune Microenvironment and Immunotherapy. | Liu, JQ., et al. 2020. Adv Exp Med Biol. 1223: 155-165. PMID: 32030689
- CD200 maintains the region-specific phenotype of microglia in the midbrain and its role in Parkinson's disease. | Wang, L., et al. 2020. Glia. 68: 1874-1890. PMID: 32112601
- CD200 and Chronic Lymphocytic Leukemia: Biological and Clinical Relevance. | D'Arena, G., et al. 2020. Front Oncol. 10: 584427. PMID: 33324560
- Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke. | Al Mamun, A., et al. 2021. Stroke. 52: 3362-3373. PMID: 34353112
- Mathematical Modeling and Analysis of CD200-CD200R in Cancer Treatment. | Liao, KL. and Watt, KD. 2022. Bull Math Biol. 84: 82. PMID: 35792958
- CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. | Morgan, HJ., et al. 2022. J Clin Invest. 132: PMID: 36074574
- PD1hi CD200hi CD4+ exhausted T cell increase immunotherapy resistance and tumour progression by promoting epithelial-mesenchymal transition in bladder cancer. | Wu, C., et al. 2023. Clin Transl Med. 13: e1303. PMID: 37313656
- Different mechanisms of CD200-CD200R induce diverse outcomes in cancer treatment. | Liao, KL., et al. 2023. Math Biosci. 365: 109072. PMID: 37734537
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OX2 Antibody (2Q1778) | sc-71761 | 200 µg/ml | $322.00 | |||
OX2 Antibody (2Q1778) FITC | sc-71761 FITC | 200 µg/ml | $336.00 | |||
OX2 Antibody (2Q1778) PE | sc-71761 PE | 200 µg/ml | $349.00 |