OV-90 Whole Cell Lysate: sc-364191

OV-90 whole cell lysate is derived from the OV-90 cell line, originally isolated from the malignant ascites of a patient with serous adenocarcinoma of the ovary. This lysate is widely utilized in research to study ovarian cancer biology and the molecular mechanisms of tumorigenesis and metastasis. OV-90 cells are known for their genetic stability and represent high-grade serous ovarian carcinoma, making the lysate an essential tool for investigating signaling pathways involved in cancer progression. Researchers employ OV-90 whole cell lysate to examine key pathways such as the PI3K/Akt/mTOR and MAPK/ERK cascades, which are crucial for cell proliferation, survival, and migration. This lysate is instrumental in studying the expression and post-translational modifications of proteins associated with these pathways, as well as their interactions with other signaling molecules. Additionally, OV-90 whole cell lysate is used to evaluate the effects of various chemical modulators on these signaling pathways, providing insights into the regulatory mechanisms of cancer cell behavior. Recent studies have leveraged this lysate for proteomic and transcriptomic analyses to identify potential biomarkers and novel targets related to ovarian cancer. By offering detailed insights into the molecular and cellular mechanisms of ovarian cancer, OV-90 whole cell lysate continues to be a critical resource for advancing oncological research.

OV-90 Whole Cell Lysate References:

1. Plakoglobin Reduces the in vitro Growth, Migration and Invasion of Ovarian Cancer Cells Expressing N-Cadherin and Mutant p53.  |  Alaee, M., et al. 2016. PLoS One. 11: e0154323. PMID: 27144941
2. Caspase-2 and oxidative stress underlie the immunogenic potential of high hydrostatic pressure-induced cancer cell death.  |  Moserova, I., et al. 2017. Oncoimmunology. 6: e1258505. PMID: 28197379