Molecular structure of Ouabain Octahydrate, CAS Number: 11018-89-6
Ouabain Octahydrate (CAS 11018-89-6)
See product citations (11)
Alternate Names:
g-Strophanthin Octahydrate; gamma-Strophanthin
Application:
Ouabain Octahydrate is a potent Na+/K+-ATPase inhibitor
CAS Number:
11018-89-6
Purity:
≥95%
Molecular Weight:
728.77
Molecular Formula:
C29H44O12•8H2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ouabain Octhahydrate is a compound that can be biosynthesized in the adrenal glands and controlled by adrenocorticotropic hormone, epinephrine, and angiotensin II. Ouabain Octhahydrate may act to inhibit Na+/K+-ATPase which results in the down-regulation of mRNA transcripts encoding several 14-3-3 gene isoforms. In the human eye, 14-3-3 proteins are multifunctional regulatory proteins and their reduction can cause profound effects on cell function. Na+/K+-ATPase is a cardiac sodium pump and influences contractility via regulation of cardiac and smooth muscle cell proliferation.
Ouabain Octahydrate (CAS 11018-89-6) References
- Regioselective derivatization of ouabain with trialkylsilyl reagents and selective oxidation of the unprotected alcohols. | Templeton, JF., et al. 2000. Steroids. 65: 379-86. PMID: 10899537
- Digitalis and digitalislike compounds down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens. | Lichtstein, D., et al. 2000. Hypertens Res. 23 Suppl: S51-3. PMID: 11016820
- Endogenous cardiac glycosides, a new class of steroid hormones. | Schoner, W. 2002. Eur J Biochem. 269: 2440-8. PMID: 12027881
- Calpain is a mediator of myocardial injury in experimental uremia: is it activated by endogenous ouabain? | Harwood, SM., et al. 2003. Kidney Int Suppl. S177-80. PMID: 12694339
- Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. | Veldhuis, WB., et al. 2003. J Neurosci. 23: 4127-33. PMID: 12764100
- Increase in molecular rigidity of the protein conformation of brain Na+-K+-ATPase by modification with 4-hydroxy-2-nonenal. | Miyake, H., et al. 2003. Biol Pharm Bull. 26: 1652-6. PMID: 14646165
- Anti-HSV activity of digitoxin and its possible mechanisms. | Su, CT., et al. 2008. Antiviral Res. 79: 62-70. PMID: 18353452
- Endogenous ouabain in renal Na(+) handling and related diseases. | Manunta, P., et al. 2010. Biochim Biophys Acta. 1802: 1214-8. PMID: 20226856
- Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase. | Waheed, F., et al. 2010. Am J Physiol Cell Physiol. 298: C1376-87. PMID: 20237148
- Inactivation of Src-to-ezrin pathway: a possible mechanism in the ouabain-mediated inhibition of A549 cell migration. | Shin, HK., et al. 2015. Biomed Res Int. 2015: 537136. PMID: 25866790
- Near-IR Two-Photon Fluorescent Sensor for K(+) Imaging in Live Cells. | Sui, B., et al. 2015. ACS Appl Mater Interfaces. 7: 17565-8. PMID: 26258885
- Assessing Teratogenicity from the Clustering of Abnormal Phenotypes in Individual Zebrafish Larvae. | Aalders, J., et al. 2016. Zebrafish. 13: 511-522. PMID: 27560445
- Development of the Digital Arthritis Index, a Novel Metric to Measure Disease Parameters in a Rat Model of Rheumatoid Arthritis. | Lim, MA., et al. 2017. Front Pharmacol. 8: 818. PMID: 29184498
- Cocaine suppression of triggered activity. A possible mechanism of antiarrhythmic action. | Carpentier, RG. and Sherief, HT. 1994. J Electrocardiol. 27: 35-9. PMID: 8120476
- Testing for circadian differences in lethality for intravenous ouabain in male mice. | Forrest, AB., et al. 1993. J Ethnopharmacol. 39: 161-6. PMID: 8258972
Inhibitor of:
ATP8B (P-type ATPases), ATPase, MMGT1, Na+/K+-ATPase α1, OR4N5, Pma1, and SLC41A3.Activator of:
JAK2, and Na+/K+-ATPase α2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ouabain Octahydrate, 1 g | sc-201548 | 1 g | $194.00 | |||
Ouabain Octahydrate, 5 g | sc-201548A | 5 g | $734.00 |