OU749 (CAS 519170-13-9)

OU749, known as N-[5-[(4-Methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-benzenesulfonamide, is notable in research for its role as a non-glutamine uncompetitive inhibitor of gamma-glutamyl transpeptidase (GGT), an enzyme involved in glutathione metabolism and amino acid transport. By inhibiting GGT, OU749 is used to study the enzyme′s function in these critical biological processes, and its uncompetitive inhibition suggests that it binds to the enzyme-substrate complex, offering a unique angle to explore GGT′s enzymatic kinetics and potential regulatory mechanisms. The compound′s thiadiazole and benzenesulfonamide moieties may contribute to its binding affinity and specificity, making it a valuable probe for elucidating the structural requirements for GGT inhibition. Researchers utilize OU749 to dissect the enzyme′s role in cellular processes, such as oxidative stress response and detoxification pathways, which can lead to a deeper understanding of GGT′s involvement in biological systems and contribute to the design of novel inhibitors with potential research applications.