OTA Antibody (3C5): sc-57948

OTA Antibody (3C5) is a mouse monoclonal IgG1 antibody that detects OTA protein of non-species reactive by enzyme-linked immunosorbent assay (ELISA). Anti-OTA antibody (3C5) is available as the non-conjugated isotype antibody. Ochratoxin A (OTA) is a potent mycotoxin primarily produced by certain species of Aspergillus and Penicillium verrucosum, a common storage fungus found in regions such as Canada, Europe, and parts of South America. This toxin is notorious for nephrotoxic effects, leading to both acute and chronic kidney damage in various animal species, and poses significant health risks to humans as well. OTA is commonly found in a variety of food products, including grains, cereals, animal feeds, and meats, and is primarily ingested through contaminated pork and grain products. OTA′s structure enables binding to serum albumin, which facilitates distribution throughout the body and enhances nephrotoxic effects. OTA is rapidly absorbed in the gastrointestinal tract and can be hydrolyzed by intestinal microflora into less harmful compounds, which are then excreted in urine and feces. Given widespread occurrence and high carcinogenic potential, OTA represents a serious health hazard, making detection and quantification critical for food safety and public health.

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OTA Antibody (3C5) References:

1. Meningeal melanocytoma associated with ipsilateral nevus of Ota presenting as intracerebral hemorrhage: case report.  |  Hino, K., et al. 2005. Neurosurgery. 56: E1376; discussion E1376. PMID: 15918956
2. Two primer pairs to detect OTA producers by PCR method.  |  Dao, HP., et al. 2005. Int J Food Microbiol. 104: 61-7. PMID: 15975678
3. Stability of ochratoxin A (OTA) during processing and decaffeination in commercial roasted coffee beans.  |  Nehad, EA., et al. 2005. Food Addit Contam. 22: 761-7. PMID: 16147432
4. The effects of yeasts involved in the fermentation of Coffea arabica in East Africa on growth and ochratoxin A (OTA) production by Aspergillus ochraceus.  |  Masoud, W. and Kaltoft, CH. 2006. Int J Food Microbiol. 106: 229-34. PMID: 16213049
5. Further arguments in favour of direct covalent binding of Ochratoxin A (OTA) after metabolic biotransformation.  |  Pfohl-Leszkowicz, A. and Castegnaro, M. 2005. Food Addit Contam. 22 Suppl 1: 75-87. PMID: 16332625
6. [Calcium concentration in the skin of male rats exposed to high doses of ochratoxin A (OTA)].  |  Bulikowski, W., et al. 2005. Med Pr. 56: 363-6. PMID: 16483006
7. A mechanical evaluation of two fixation methods using cancellous screws for coronal fractures of the lateral condyle of the distal femur (OTA type 33B).  |  Jarit, GJ., et al. 2006. J Orthop Trauma. 20: 273-6. PMID: 16721243
8. Kinetics and spatial distribution of OTA in Aspergillus carbonarius cultures.  |  Valero, A., et al. 2006. Food Microbiol. 23: 753-6. PMID: 16943078
9. Ochratoxin A: an important western Canadian storage mycotoxin.  |  Marquardt, RR., et al. 1990. Can J Physiol Pharmacol. 68: 991-9. PMID: 2200593