Ostreogrycin A CAS: 21411-53-0
MF: C28H35N3O7
MW: 525.6
A bacteriostatic inhibitor of translation at the 50S ribosome.

Ostreogrycin A (CAS 21411-53-0)

Ostreogrycin A | CAS 21411-53-0 is rated 4.0 out of 5 by 1.
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Synonym: Virginiamycin M; Mikamycin A; Staphylomycin; Pristinamycin IIA
Application: A bacteriostatic inhibitor of translation at the 50S ribosome
CAS Number: 21411-53-0
Purity: >99%
Molecular Weight: 525.6
Molecular Formula: C28H35N3O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ostreogrycin A, also known as Virginiamycin M1, is a streptogramin macrolide antibiotic. Ostreogrycin A interacts with the bacterial 50S ribosome, inhibiting its function in a reversible manner. Activity of Ostreogrycin A at the ribosome blocks translation and produces a bacteriostatic effect. With addition of Virginiamycin S1 (sc-202384), the two antibiotics produce a synergistic bacteriocidal effect. The combination of these compounds, available as a Virginimycin complex (sc-202383), demonstrate efficacy against a broad range of bacteria.


References

1. Crooy, P. and De Neys, R. 1972. J. Antibiot. 25: 371-372. PMID: 4568014
2. Parfait, R. and Cocito, C. 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 5492-5496. PMID: 6776538
3. Cocito, C. and Chinali, G. 1985. J. Antimicrob. Chemother. 16: 35-52. PMID: 3932310
4. Odom, O.W. and Hardesty, B. 1992. J. Biol. Chem. 267: 19117-19122. PMID: 1527036
5. Vannuffel, P., et al. 1994. Nucleic Acids Res. 22: 4449-4453. PMID: 7971275
6. Porse, B.T. and Garrett, R.A. 1999. J. Mol. Biol. 286: 375-387. PMID: 9973558
7. Champney, W.S. and Tober, C.L. 2000. Curr. Microbiol. 41: 126-135. PMID: 10856379

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in water (partly), ethanol (4%), methanol (4%), DMF, and DMSO.
Storage :
Store at -20° C
Melting Point :
165-167.2° C (dec.)
Boiling Point :
825.22° C at 760 mmHg (Predicted)
Density :
1.27 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α20/D -180.77°, c = 0.52 in ethanol
pK Values :
pKa: 13.18 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16220095
Merck Index :
14: 10004
MDL Number :
MFCD00869411
EC Number :
244-376-6
SMILES :
C[[email protected]@H]1/C=C\\C(=O)NC/C=C\\C(=C/[[email protected]](CC(=O)CC2=NC(=CO2)C(=O)N3CCC=C3C(=O)O[[email protected]@H]1C(C)C)O)\\C

Download SDS (MSDS)

Certificate of Analysis

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Date published: 2015-04-20
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