Molecular structure of Ostreogrycin A, CAS Number: 21411-53-0
Ostreogrycin A (CAS 21411-53-0)
Alternate Names:
Virginiamycin M; Mikamycin A; Staphylomycin; Pristinamycin IIA
Application:
Ostreogrycin A is a bacteriostatic inhibitor of translation at the 50S ribosome
CAS Number:
21411-53-0
Purity:
>99%
Molecular Weight:
525.6
Molecular Formula:
C28H35N3O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ostreogrycin A, also known as Virginiamycin M1, is a streptogramin macrolide antibiotic. Ostreogrycin A interacts with the bacterial 50S ribosome, inhibiting its function in a reversible manner. Activity of Ostreogrycin A at the ribosome blocks translation and produces a bacteriostatic effect. With addition of Virginiamycin S1 (sc-202384), the two antibiotics produce a synergistic bacteriocidal effect. The combination of these compounds, available as a Virginimycin complex (sc-202383), demonstrate efficacy against a broad range of bacteria.
Ostreogrycin A (CAS 21411-53-0) References
- Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. | Champney, WS. and Tober, CL. 2000. Curr Microbiol. 41: 126-35. PMID: 10856379
- Antibiotics of the virginiamycin family, inhibitors which contain synergistic components. | Cocito, C. 1979. Microbiol Rev. 43: 145-92. PMID: 117294
- Use of 50 S-binding antibiotics to characterize the ribosomal site to which peptidyl-tRNA is bound. | Odom, OW. and Hardesty, B. 1992. J Biol Chem. 267: 19117-22. PMID: 1527036
- Solvent affects the conformation of virginiamycin M1 (pristinamycin IIA, streptogramin A). | Dang, J., et al. 2004. Org Biomol Chem. 2: 2919-24. PMID: 15480455
- Highly regioselective palladium-catalyzed direct arylation of oxazole at C-2 or C-5 with aryl bromides, chlorides, and triflates. | Strotman, NA., et al. 2010. Org Lett. 12: 3578-81. PMID: 20704397
- Molecular mechanism of action of virginiamycin-like antibiotics (synergimycins) on protein synthesis in bacterial cell-free systems. | Cocito, C. and Chinali, G. 1985. J Antimicrob Chemother. 16 Suppl A: 35-52. PMID: 3932310
- Virginiamycin: nomenclature. | Crooy, P. and De Neys, R. 1972. J Antibiot (Tokyo). 25: 371-2. PMID: 4568014
- Tissue residue studies in swine treated with virginiamycin. | DiCuollo, CJ., et al. 1973. J Agric Food Chem. 21: 818-21. PMID: 4582096
- Lasting damage to bacterial ribosomes by reversibly bound virginiamycin M. | Parfait, R. and Cocito, C. 1980. Proc Natl Acad Sci U S A. 77: 5492-6. PMID: 6776538
- Chemical probing of a virginiamycin M-promoted conformational change of the peptidyl-transferase domain. | Vannuffel, P., et al. 1994. Nucleic Acids Res. 22: 4449-53. PMID: 7971275
- Plasmid-mediated pristinamycin resistance. PAC IIA: a new enzyme which modifies pristinamycin IIA. | Goffic, FL., et al. 1977. J Antibiot (Tokyo). 30: 665-9. PMID: 908665
- Applications of mass spectrometry to the analysis of mycotoxins. | Kingston, DG. 1976. J Assoc Off Anal Chem. 59: 1016-22. PMID: 965324
- Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms. | Porse, BT. and Garrett, RA. 1999. J Mol Biol. 286: 375-87. PMID: 9973558
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TYSND1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ostreogrycin A, 5 mg | sc-202269 | 5 mg | $422.00 |