Molecular structure of Ostarine, CAS Number: 841205-47-8
Ostarine (CAS 841205-47-8)
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Alternate Names:
Ostarine is also known as Enobosarm.
Application:
Ostarine is a selective modulator to human androgen receptor with anabolic activity, mimicking testosterone′s action.
CAS Number:
841205-47-8
Molecular Weight:
389.33
Molecular Formula:
C19H14F3N3O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ostarine is a selective androgen receptor modulator (SARM) with anabolic activity. It is designed to work like testosterone. The selective anabolic effects of Ostarine are supported by a lack of PSA increases in men and hair growth in women. It has an ED50 of 0.44 mg/day. Ostarine (MK-2866) also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio for all doses remaining in the low cardiovascular risk catergory. At the concentration of 10 nM, it modulates the transcriptional activity of AR in CV-1 cells cotransfected with a human AR expression vector, a luciferase reporter vector, and a control β-galactosidase vector, with 94%-100% relative activity of the transcriptional activation observed for 1 nM DHT.
Ostarine (CAS 841205-47-8) References
- The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulators. | Kim, J., et al. 2005. J Pharmacol Exp Ther. 315: 230-9. PMID: 15987833
- Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets. | Duke, CB., et al. 2011. J Med Chem. 54: 3973-6. PMID: 21506597
- Miscellaneous agents--cytotoxics and hormonal agents. | Gerber, DE. 2012. J Thorac Oncol. 7: S387-9. PMID: 23160328
- Computer-aided (in silico) approaches in the mode-of-action analysis and safety assessment of ostarine and 4-methylamphetamine. | Mohd Fauzi, F., et al. 2013. Hum Psychopharmacol. 28: 365-78. PMID: 23881885
- Absorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide] in rats. | Kim, J., et al. 2013. Xenobiotica. 43: 993-1009. PMID: 24074268
- Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer. | Dalton, JT., et al. 2013. Curr Opin Support Palliat Care. 7: 345-51. PMID: 24189892
- Enobosarm (GTx-024, S-22): a potential treatment for cachexia. | Srinath, R. and Dobs, A. 2014. Future Oncol. 10: 187-94. PMID: 24490605
- Therapies for musculoskeletal disease: can we treat two birds with one stone? | Girgis, CM., et al. 2014. Curr Osteoporos Rep. 12: 142-53. PMID: 24633910
- Evaluation of ostarine as a selective androgen receptor modulator in a rat model of postmenopausal osteoporosis. | Hoffmann, DB., et al. 2019. J Bone Miner Metab. 37: 243-255. PMID: 29785666
- The Selective Androgen Receptor Modulator Ostarine Improves Bone Healing in Ovariectomized Rats. | Komrakova, M., et al. 2020. Calcif Tissue Int. 106: 147-157. PMID: 31531719
- Effect of ostarine (enobosarm/GTX024), a selective androgen receptor modulator, on adipocyte metabolism in Wistar rats. | Leciejewska, N., et al. 2019. J Physiol Pharmacol. 70: PMID: 31642815
- Elimination profiles of microdosed ostarine mimicking contaminated products ingestion. | Walpurgis, K., et al. 2020. Drug Test Anal. 12: 1570-1580. PMID: 32959982
- Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model. | Roch, PJ., et al. 2020. Front Endocrinol (Lausanne). 11: 556581. PMID: 33042018
- Ostarine attenuates pyocyanin in Pseudomonas aeruginosa by interfering with quorum sensing systems. | Dong, L., et al. 2021. J Antibiot (Tokyo). 74: 863-873. PMID: 34480092
- Ostarine-Induced Myogenic Differentiation in C2C12, L6, and Rat Muscles. | Leciejewska, N., et al. 2022. Int J Mol Sci. 23: PMID: 35457222
Inhibitor of:
Androgen Receptor, EG623898, SARM, SRMS, and TR2.Activator of:
GDF-8, and Myf-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ostarine, 5 mg | sc-364559 | 5 mg | $270.00 | |||
Ostarine, 50 mg | sc-364559A | 50 mg | $1549.00 | |||
Ostarine, 1 kg | sc-364559B | 1 kg | $9180.00 |