Ospemifene (CAS 128607-22-7)
See product citations (1)
Alternate Names:
FC-1271a
CAS Number:
128607-22-7
Molecular Weight:
378.89
Molecular Formula:
C24H23ClO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ospemifene is recognized for its role in modulating estrogen receptors, where it functions by selectively interacting with these receptors in various tissues. Unlike traditional estrogens, ospemifene has a unique ability to either mimic or block the action of estrogen depending on the context, making it a selective estrogen receptor modulator (SERM). This property enables it to exhibit a wide range of biochemical activities across different tissue types, influencing cellular processes that are regulated by estrogen receptors. the study of ospemifene′s mechanism offers insights into the design of compounds with selective activity on estrogen receptors, contributing to research in fields like biochemistry and molecular biology.
Ospemifene (CAS 128607-22-7) References
- In vitro and in vivo biologic effects of Ospemifene (FC-1271a) in breast cancer. | Taras, TL., et al. 2001. J Steroid Biochem Mol Biol. 77: 271-9. PMID: 11457665
- Comparative study of the short-term effects of a novel selective estrogen receptor modulator, ospemifene, and raloxifene and tamoxifen on rat uterus. | Zheng, H., et al. 2004. J Steroid Biochem Mol Biol. 88: 143-56. PMID: 15084346
- Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar mice. | Wurz, GT., et al. 2005. J Steroid Biochem Mol Biol. 97: 230-40. PMID: 16153821
- Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro. | Michael, H., et al. 2007. Br J Pharmacol. 151: 384-95. PMID: 17420779
- Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gamma-inducible protein-10 by astrocytes exposed to inflammatory challenge in vitro. | Cerciat, M., et al. 2010. Glia. 58: 93-102. PMID: 19533603
- Ospemifene and 4-hydroxyospemifene effectively prevent and treat breast cancer in the MTag.Tg transgenic mouse model. | Burich, RA., et al. 2012. Menopause. 19: 96-103. PMID: 21926925
- Effects of the selective estrogen receptor modulator ospemifene on bone in rats. | Kangas, L., et al. 2014. Horm Metab Res. 46: 27-35. PMID: 24108389
- The Effect of Selective Estrogen Receptor Modulators (SERMs) on the Tamoxifen Resistant Breast Cancer Cells. | Chang, BY., et al. 2011. Toxicol Res. 27: 85-93. PMID: 24278556
- Effects of ospemifene on breast tissue morphology and proliferation: a comparative study versus other selective estrogen receptor modulators in ovariectomized rats. | Kangas, L., et al. 2014. Horm Metab Res. 46: 328-32. PMID: 24526372
- Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors. | Peretz, J., et al. 2016. Am J Physiol Lung Cell Mol Physiol. 310: L415-25. PMID: 26684252
- Effects of ospemifene, a novel selective estrogen-receptor modulator, on human breast tissue ex vivo. | Eigeliene, N., et al. 2016. Menopause. 23: 719-30. PMID: 27163517
- Effects of vaginal conjugated equine estrogens and ospemifene on the rat vaginal wall and lower urinary tract. | Maldonado, PA., et al. 2017. Biol Reprod. 96: 81-92. PMID: 28395337
- Ospemifene displays broad-spectrum synergistic interactions with itraconazole through potent interference with fungal efflux activities. | Eldesouky, HE., et al. 2020. Sci Rep. 10: 6089. PMID: 32269301
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ospemifene, 10 mg | sc-478396 | 10 mg | $94.00 | |||
Ospemifene, 50 mg | sc-478396A | 50 mg | $146.00 | |||
Ospemifene, 100 mg | sc-478396B | 100 mg | $198.00 | |||
Ospemifene, 200 mg | sc-478396C | 200 mg | $291.00 | |||
Ospemifene, 10 g | sc-478396D | 10 g | $1467.00 | |||
Ospemifene, 100 g | sc-478396E | 100 g | $4120.00 | |||
Ospemifene, 1 kg | sc-478396F | 1 kg | $20818.00 |