OSM Antibody (B-6): sc-133229

OSM Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects Oncostatin M (OSM) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-OSM antibody (B-6) plays a crucial role in understanding the function of OSM, a glycoprotein that is pivotal in regulating cell growth and differentiation, particularly in hematopoietic cells. OSM (B-6) antibody enables detection of this protein, known for inhibiting proliferation of various human tumor cell lines while sparing normal human fibroblasts, highlighting OSM′s potential as a therapeutic target in cancer treatment. High-affinity binding sites for OSM are found on both normal and tumor cells, underscoring OSM′s importance in cellular signaling pathways. OSM expression is notably elevated in activated monocytic and lymphocytic cell lines, as well as in normal adherent macrophages, indicating OSM′s role in immune responses. OSM′s amino acid sequence shows homology with other critical cytokines such as leukemia inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6, all involved in the growth and differentiation of various cell types. OSM (B-6) monoclonal antibody enables researchers to gain valuable insights into OSM′s biological functions and interactions, furthering understanding of OSM′s implications in health and disease.

The preferred OSM antibody is OSM Antibody (A-9): sc-374039.