Molecular structure of OSI-420, Free Base (Desmethyl Erlotinib), CAS Number: 183321-86-0
OSI-420, Free Base (Desmethyl Erlotinib) (CAS 183321-86-0)
See product citations (2)
Alternate Names:
2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol; CP 373420
Application:
OSI-420, Free Base (Desmethyl Erlotinib) is a metabolite of Erlotinib
CAS Number:
183321-86-0
Purity:
≥98%
Molecular Weight:
379.41
Molecular Formula:
C21H21N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A metabolite of Erlotinib which is an anti cancer agent.
OSI-420, Free Base (Desmethyl Erlotinib) (CAS 183321-86-0) References
- Specific method for determination of OSI-774 and its metabolite OSI-420 in human plasma by using liquid chromatography-tandem mass spectrometry. | Zhao, M., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 793: 413-20. PMID: 12906916
- Simultaneous determination of OSI-774 and its major metabolite OSI-420 in human plasma by using HPLC with UV detection. | Zhang, W., et al. 2005. J Chromatogr B Analyt Technol Biomed Life Sci. 814: 143-7. PMID: 15607718
- The current situation: erlotinib (Tarceva) and gefitinib (Iressa) in non-small cell lung cancer. | Comis, RL. 2005. Oncologist. 10: 467-70. PMID: 16079313
- Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteers. | Ling, J., et al. 2006. Drug Metab Dispos. 34: 420-6. PMID: 16381666
- The quantification of erlotinib (OSI-774) and OSI-420 in human plasma by liquid chromatography-tandem mass spectrometry. | Masters, AR., et al. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 848: 379-83. PMID: 17101305
- The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates. | Meany, HJ., et al. 2008. Cancer Chemother Pharmacol. 62: 387-92. PMID: 17932674
- A validated liquid chromatography tandem mass spectrometry method for quantification of erlotinib, OSI-420 and didesmethyl erlotinib and semi-quantification of erlotinib metabolites in human plasma. | Svedberg, A., et al. 2015. J Pharm Biomed Anal. 107: 186-95. PMID: 25594896
- Bioanalysis of erlotinib, its O-demethylated metabolites OSI-413 and OSI-420, and other metabolites by liquid chromatography-tandem mass spectrometry with additional ion mobility identification. | Rood, JJM., et al. 2021. J Chromatogr B Analyt Technol Biomed Life Sci. 1166: 122554. PMID: 33540147
- Simultaneous quantification of atorvastatin, erlotinib and OSI-420 in rat serum and liver microsomes using a novel liquid chromatography-mass spectrometry method. | Rysz, MA., et al. 2023. J Pharm Biomed Anal. 236: 115716. PMID: 37722165
- Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. | Rusch, V., et al. 1993. Cancer Res. 53: 2379-85. PMID: 7683573
- Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. | Fontanini, G., et al. 1998. Clin Cancer Res. 4: 241-9. PMID: 9516978
Inhibitor of:
EGFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OSI-420, Free Base (Desmethyl Erlotinib), 1 mg | sc-212485 | 1 mg | $294.00 |