OSCAR Antibody (WW07): sc-80266

OSCAR Antibody (WW07) is a mouse monoclonal IgG2b kappa light chain antibody that detects OSCAR protein of human origin by western blotting (WB). Anti-OSCAR antibody (WW07) is available as the non-conjugated format, providing researchers with a reliable tool for studying OSCAR protein. Osteoclast-associated receptor (OSCAR) plays a pivotal role in osteoclast differentiation and is a member of the leukocyte receptor complex (LRC) protein family, which is essential for regulating both innate and adaptive immune responses. OSCAR protein is uniquely expressed in preosteoclasts and mature osteoclasts, distinguishing OSCAR from other LRC members. OSCAR′s location on the cell surface is crucial, as OSCAR facilitates interaction with the FcRgamma chain, a signal transducing adaptor molecule for Fc receptors, which is vital for OSCAR′s expression and function. This interaction not only regulates osteoclast differentiation but also influences overall bone development homeostasis. Human OSCAR is consistently expressed during CD14(+) monocyte differentiation into dendritic cells, highlighting OSCAR′s importance in immune system functionality. With specific reactivity and critical role in osteoclast biology, OSCAR monoclonal antibody (WW07) is an invaluable resource for researchers investigating bone metabolism and immune responses.

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OSCAR Antibody (WW07) References:

1. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.  |  Mócsai, A., et al. 2004. Proc Natl Acad Sci U S A. 101: 6158-63. PMID: 15073337
2. OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells.  |  Merck, E., et al. 2004. Blood. 104: 1386-95. PMID: 15155468
3. Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).  |  Ishikawa, S., et al. 2004. Int Immunol. 16: 1019-25. PMID: 15184345
4. The role of parathyroid hormone-related protein in the regulation of osteoclastogenesis by cementoblasts.  |  Boabaid, F., et al. 2004. J Periodontol. 75: 1247-54. PMID: 15515341
5. Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses.  |  Merck, E., et al. 2005. Blood. 105: 3623-32. PMID: 15650060
6. Leptomeningeal metastases of solid cancer.  |  Le Rhun, E. and Galanis, E. 2016. Curr Opin Neurol. 29: 797-805. PMID: 27661208
7. The Evolving Landscape of Brain Metastasis.  |  Valiente, M., et al. 2018. Trends Cancer. 4: 176-196. PMID: 29506669
8. Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.  |  Park, DR., et al. 2020. Nat Commun. 11: 4343. PMID: 32859940
9. Radiotherapy of cervical cancer.  |  Chargari, C., et al. 2022. Cancer Radiother. 26: 298-308. PMID: 34955418
10. Roles of osteoclast-associated receptor in rheumatoid arthritis and osteoarthritis.  |  Kim, GM., et al. 2022. Joint Bone Spine. 89: 105400. PMID: 35504517
11. Pembrolizumab in microsatellite instability high or mismatch repair deficient cancers: updated analysis from the phase II KEYNOTE-158 study.  |  Maio, M., et al. 2022. Ann Oncol. 33: 929-938. PMID: 35680043
12. Targeting the nucleolus as a therapeutic strategy in human disease.  |  Corman, A., et al. 2023. Trends Biochem Sci. 48: 274-287. PMID: 36229381

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OSCAR Antibody (WW07) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-OSCAR Antibody (WW07) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OSCAR Antibody (WW07) Specifications

Alternate Product Name: OSCAR

Product Clone Name: WW07

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: OSCAR

Epitope Species: human

Product Reactivity/Detection: OSCAR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for OSCAR Antibody (WW07): N/A