ORP-8 Antibody (PL-C26): sc-134409

ORP-8 Antibody (PL-C26) is a mouse monoclonal IgG2a kappa light chain antibody that detects the ORP-8 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ORP-8 antibody (PL-C26) is available as a non-conjugated format. ORP-8, also known as MST120, OSBP10, MSTP120, or OSBPL8, is a member of the oxysterol-binding protein (OSBP) family, which plays a crucial role in lipid metabolism and cellular signaling. ORP-8 is localized to the endoplasmic reticulum, where ORP-8 is involved in the regulation of cholesterol homeostasis by suppressing the expression of ATP-binding cassette transporter A1 (ABC1) and thereby inhibiting cholesterol efflux from macrophages. This function is particularly important in the context of atherosclerosis, as dysregulation of cholesterol transport can lead to plaque formation in blood vessels. ORP-8 exists in two isoforms due to alternative splicing, which may further influence its role in lipid metabolism and cardiovascular health. With its highly conserved OSBP-type sterol-binding region and pleckstrin homology domain, ORP-8 exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate, highlighting its significance in lipid signaling pathways.

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ORP-8 Antibody (PL-C26) References:

1. Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides.  |  Raychaudhuri, S., et al. 2006. J Cell Biol. 173: 107-19. PMID: 16585271
2. The OSBP-related proteins (ORPs): global sterol sensors for co-ordination of cellular lipid metabolism, membrane trafficking and signalling processes?  |  Olkkonen, VM., et al. 2006. Biochem Soc Trans. 34: 389-91. PMID: 16709169
3. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.  |  Suchanek, M., et al. 2007. Biochem J. 405: 473-80. PMID: 17428193
4. Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice.  |  Yan, D., et al. 2007. Arterioscler Thromb Vasc Biol. 27: 1618-24. PMID: 17478758
5. Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling.  |  Fairn, GD. and McMaster, CR. 2008. Cell Mol Life Sci. 65: 228-36. PMID: 17938859
6. OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.  |  Yan, D., et al. 2008. J Biol Chem. 283: 332-340. PMID: 17991739
7. Characteristics of oxysterol binding proteins.  |  Yan, D. and Olkkonen, VM. 2008. Int Rev Cytol. 265: 253-85. PMID: 18275891
8. Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function.  |  Ngo, M. and Ridgway, ND. 2009. Mol Biol Cell. 20: 1388-99. PMID: 19129476
9. OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids.  |  Hynynen, R., et al. 2009. J Lipid Res. 50: 1305-15. PMID: 19224871

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ORP-8 Antibody (PL-C26) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-ORP-8 Antibody (PL-C26) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ORP-8 Antibody (PL-C26) Specifications

Alternate Product Name: ORP-8

Product Clone Name: PL-C26

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 244-347

Epitope Target: ORP-8

Epitope Species: human

Product Reactivity/Detection: ORP-8

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for ORP-8 Antibody (PL-C26): N/A