Molecular structure of Orotic acid, CAS Number: 65-86-1
Orotic acid (CAS 65-86-1)
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Alternate Names:
2,6-Dihydroxypyrimidine-4-carboxylic acid; 6-Carboxyuracil
Application:
Orotic acid is an intermediate in de novo pyrimidine biosynthesis
CAS Number:
65-86-1
Purity:
97%
Molecular Weight:
156.10
Molecular Formula:
C5H4N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Orotic acid is a heterocyclic compound and an acid. It was once believed to be part of the vitamin B complex and was called vitamin B13, but it is now known that it is not a vitamin but is instead manufactured in the body by intestinal flora. It is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-alpha-d-ribose 1′-diphosphate (PRPP) to orotic acid, forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid may be used to study dependent cell signaling pathways and transcription regulation mechanisms that induce hepatic lipogenesis.
Orotic acid (CAS 65-86-1) References
- Dietary orotic acid affects antioxidant enzyme mRNA levels and oxidative damage to lipids and proteins in rat liver. | Morifuji, M. and Aoyama, Y. 2002. J Nutr Biochem. 13: 403-410. PMID: 12121827
- Conformational studies of hydantoin-5-acetic acid and orotic acid. | Gerhardt, V., et al. 2012. Acta Crystallogr C. 68: o92-8. PMID: 22307261
- Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis. | Choi, YJ., et al. 2015. Toxicol Sci. 144: 307-17. PMID: 25601987
- Sensitive and Selective Determination of Orotic Acid in Biological Specimens Using a Novel Fluorogenic Reaction. | Yin, S., et al. 2015. J Fluoresc. 25: 1005-11. PMID: 26026930
- Production of orotic acid by a Klura3Δ mutant of Kluyveromyces lactis. | Carvalho, N., et al. 2016. J Biosci Bioeng. 121: 625-630. PMID: 26707627
- Highly Water-Soluble Orotic Acid Nanocrystals Produced by High-Energy Milling. | de Cássia Zaghi Compri, J., et al. 2019. J Pharm Sci. 108: 1848-1856. PMID: 30599168
- Photodegradation and Biodegradation of Poly(Lactic) Acid Containing Orotic Acid as a Nucleation Agent. | Salač, J., et al. 2019. Materials (Basel). 12: PMID: 30720761
- Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism. | Matilainen, J., et al. 2020. Lipids Health Dis. 19: 70. PMID: 32284043
- Effects of Cyclic High Ambient Temperature and Dietary Supplementation of Orotic Acid, a Pyrimidine Precursor, on Plasma and Muscle Metabolites in Broiler Chickens. | Shimamoto, S., et al. 2020. Metabolites. 10: PMID: 32408619
- A toxicological evaluation of lithium orotate. | Murbach, TS., et al. 2021. Regul Toxicol Pharmacol. 124: 104973. PMID: 34146638
- Orotic acid production by Yarrowia lipolytica under conditions of limited pyrimidine. | Swietalski, P., et al. 2022. Yeast. 39: 230-240. PMID: 34648204
- Orotic acid protects pancreatic β cell by p53 inactivation in diabetic mouse model. | Fushimura, Y., et al. 2021. Biochem Biophys Res Commun. 585: 191-195. PMID: 34813979
- Sea Cucumber Saponins Derivatives Alleviate Hepatic Lipid Accumulation Effectively in Fatty Acids-Induced HepG2 Cells and Orotic Acid-Induced Rats. | Li, X., et al. 2022. Mar Drugs. 20: PMID: 36355027
- Orotic Acid as a Bifunctional Additive for Regulating Crystallization and Passivating Defects toward High-Performance Formamidinium-Cesium Perovskite Solar Cells. | Ni, M. and Qi, L. 2022. ACS Appl Mater Interfaces. 14: 53808-53818. PMID: 36414242
- An Investigation on the Efficacy of Orotic Acid as a Bio-Nucleating Agent for Poly-Lactic Acid under Quiescent Condition and Injection Molding. | Gao, P., et al. 2022. Micromachines (Basel). 13: PMID: 36557485
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Orotic acid, 25 g | sc-215637 | 25 g | $40.00 | |||
Orotic acid, 100 g | sc-215637A | 100 g | $146.00 | |||
Orotic acid, 1 kg | sc-215637B | 1 kg | $607.00 |