Molecular structure of Orbifloxacin, CAS Number: 113617-63-3
Orbifloxacin (CAS 113617-63-3)
Alternate Names:
1-Cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxo-quinoline-3-carboxylic acid; Orbax
Application:
Orbifloxacin is a particularly strong antibiotic against staphyloccal infections n vitro
CAS Number:
113617-63-3
Molecular Weight:
395.38
Molecular Formula:
C19H20F3N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Orbifloxacin is a particularly strong antibiotic against staphyloccal infections n vitro. It is an antibacterial fluoroquinolone derivative. Inhibits bacterial growth by inhibiting DNA gyrase and topoisomerase IV. May be used as a reference standard in the estimation of orbifloxacin in pharmaceutical formulations using UV spectrophotometric technique.
Orbifloxacin (CAS 113617-63-3) References
- Pharmacokinetics of orbifloxacin and its concentration in body fluids and in endometrial tissues of mares. | Haines, GR., et al. 2001. Can J Vet Res. 65: 181-7. PMID: 11480524
- In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections. | Ganière, JP., et al. 2004. Res Vet Sci. 77: 67-71. PMID: 15120955
- Pharmacokinetics and milk penetration of orbifloxacin after intravenous, subcutaneous, and intramuscular administration to lactating goats. | Marín, P., et al. 2007. J Dairy Sci. 90: 4219-25. PMID: 17699040
- Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of orbifloxacin in Korean Hanwoo cattle. | Elias, G., et al. 2009. J Vet Pharmacol Ther. 32: 219-28. PMID: 19646085
- Post-antibiotic effect of orbifloxacin against Escherichia coli and Pseudomonas aeruginosa isolates from dogs. | Harada, K., et al. 2012. Acta Vet Scand. 54: 16. PMID: 22433170
- Determination of orbifloxacin in sheep plasma by high performance liquid chromatography with ultraviolet detection after intravenous and intramuscular administration. | Dudhatra, GB., et al. 2013. J Pharmacol Toxicol Methods. 67: 50-3. PMID: 23231925
- Pharmacokinetics and bioavailability of orbifloxacin oral suspension in New Zealand White rabbits (Oryctolagus cuniculus). | Watson, MK., et al. 2015. Am J Vet Res. 76: 946-51. PMID: 26512539
- Development of a multiroute physiologically based pharmacokinetic model for orbifloxacin in rabbits. | Yang, F., et al. 2018. J Vet Pharmacol Ther. 41: 622-631. PMID: 29457247
- Pharmacokinetics of orbifloxacin in crucian carp (Carassius auratus) after intravenous and intramuscular administration. | Yang, F., et al. 2018. J Vet Pharmacol Ther. 41: 599-604. PMID: 29465160
- Disposition kinetics of orbifloxacin in tissues of crucian carp (Carassius auratus) following a single intramuscular administration. | Yang, YR., et al. 2019. Iran J Vet Res. 20: 131-135. PMID: 31531036
- Pharmacokinetics in plasma and alveolar regions of a healthy calf intramuscularly administered a single dose of orbifloxacin. | Kuramae, T., et al. 2022. J Vet Med Sci. 84: 400-405. PMID: 35095059
- Development and application of a physiologically based pharmacokinetic model for orbifloxacin in crucian carp (Carassius auratus). | Yang, F., et al. 2022. J Vet Pharmacol Ther. 45: 311-319. PMID: 35243644
- A pharmacodynamic investigation to assess the synergism of orbifloxacin and propyl gallate against Escherichia coli. | Abbas, MA., et al. 2022. Front Pharmacol. 13: 989395. PMID: 36188537
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Orbifloxacin, 100 mg | sc-224179 | 100 mg | $86.00 |