Molecular structure of Ophthalmic Acid, CAS Number: 495-27-2
Ophthalmic Acid (CAS 495-27-2)
See product citations (2)
Alternate Names:
L-gamma-Glutamyl-L-alpha-aminobutyrylglycine
Application:
Ophthalmic Acid is an analogue of glutathione isolated from the lens
CAS Number:
495-27-2
Molecular Weight:
289.29
Molecular Formula:
C11H19N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ophthalmic Acid is an analogue of glutathione that has been observed to be produced in the kidneys and liver in vivio from precursors L-.alpha.-aminobutyrate or L-.gamma.-glutamyl-L-.alpha.-aminobutyrate. The compound has also been detected in the lens. In metabolomics research the detection of Opthalmic Acid in mouse serum was a sensitive indicator of depleted hepatic GSH.
Ophthalmic Acid (CAS 495-27-2) References
- Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. | Soga, T., et al. 2006. J Biol Chem. 281: 16768-76. PMID: 16608839
- Ophthalmic acid accumulation in an Escherichia coli mutant lacking the conserved pyridoxal 5'-phosphate-binding protein YggS. | Ito, T., et al. 2016. J Biosci Bioeng. 122: 689-693. PMID: 27426274
- 2-Aminobutyric acid modulates glutathione homeostasis in the myocardium. | Irino, Y., et al. 2016. Sci Rep. 6: 36749. PMID: 27827456
- Increased ophthalmic acid production is supported by amino acid catabolism under fasting conditions in mice. | Kobayashi, S., et al. 2017. Biochem Biophys Res Commun. 491: 649-655. PMID: 28757411
- Ophthalmic acid is a marker of oxidative stress in plants as in animals. | Servillo, L., et al. 2018. Biochim Biophys Acta Gen Subj. 1862: 991-998. PMID: 29413907
- Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans. | Kim Mc van, M., et al. 2018. J Clin Transl Res. 3: 366-374. PMID: 30873484
- Measurement of the tripeptides glutathione and ophthalmic acid by gas chromatography-mass spectrometry. | Bollenbach, A. and Tsikas, D. 2022. Anal Biochem. 644: 113841. PMID: 32721386
- Ophthalmic acid is a glutathione regulating tripeptide. | Schomakers, BV., et al. 2024. FEBS J.. PMID: 38245827
- Synthesis of ophthalmic acid in liver and kidney in vivo. | Orlowski, M. and Wilk, S. 1978. Biochem J. 170: 415-9. PMID: 637852
- Ophthalmic and norophthalmic acid in lens, liver, and brain of higher animals. | Tsuboi, S., et al. 1984. Anal Biochem. 136: 520-4. PMID: 6721150
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ophthalmic Acid, 250 mg | sc-295979 | 250 mg | $695.00 | |||
Ophthalmic Acid, 1 g | sc-295979A | 1 g | $1600.00 |