Molecular structure of ON-01910, CAS Number: 1225497-78-8
ON-01910 (CAS 1225497-78-8)
Alternate Names:
Novonex; Estybon; Rigosertib sodium; Estybon
Application:
ON-01910 is a PLK1 and PLK2 inhibitor
CAS Number:
1225497-78-8
Purity:
≥99%
Molecular Weight:
473.43
Molecular Formula:
C21H24NO8S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ON-01910 is an inhibitor to PLK1 with IC50 of 9 nM. ON-01910 also inhibits PLK2, PDGFR, Flt1, BCR-ABL, Fyn, Src, and CDK1, with IC50 of 18–260 nM. ON-01910 shows cell killing activity against 94 different tumor cell lines with IC50 of 50–250 nM, including BT27, MCF-7, DU145, PC3, U87, A549, H187, RF1, HCT15, SW480, and KB cells. In HeLa cells, ON-01910 (100–250 nM) induces spindle abnormalities and apoptosis. ON-01910 also inhibits several multidrug resistant tumor cell lines.
Inhibitor of:
53BP1, BC061194, Bcr, Cdc5, Cdk, Cdk1, Forkhead box N (FOXN), H-plk, Plk, SDCCAG1, Snk, and SRC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ON-01910, 5 mg | sc-364556 | 5 mg | $300.00 | |||
ON-01910, 10 mg | sc-364556A | 10 mg | $700.00 |