OMP Antibody (B-6): sc-365818

OMP Antibody (B-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects the olfactory marker protein (OMP) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-OMP antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The olfactory marker protein plays a crucial role in the olfactory system, particularly in the cytoplasm of olfactory chemosensory neurons located in the nasal neuroepithelium, where OMP serves as a marker of mature vertebrate olfactory receptor neurons. OMP is synthesized in the neuronal cell bodies and subsequently transported into axons and terminals in the olfactory bulb, where OMP is translated. Notably, OMP has been shown to interact with brain-expressed X-linked genes Bex1 and Bex2, which may influence neuronal signaling pathways. Additionally, OMP is believed to have a modulatory role in the odor detection and signal transduction cascade, enhancing the sensitivity of olfactory responses. In fetal olfactory epithelial cells, OMP acts as a potent enhancer of mitosis, promoting increased uptake of tritiated thymidine in the liver. The deletion of OMP has been linked to a diminished ability to respond to odor stimuli and an increase in behavioral threshold sensitivity, underscoring OMP′s importance in olfactory function and development.

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OMP Antibody (B-6) References:

1. TGF-alpha and olfactory marker protein enhance mitosis in rat olfactory epithelium in vivo.  |  Farbman, AI. and Ezeh, PI. 2000. Neuroreport. 11: 3655-8. PMID: 11095538
2. Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners.  |  Behrens, M., et al. 2003. J Neurochem. 86: 1289-96. PMID: 12911636
3. Expression of Bcl-2 extends the survival of olfactory receptor neurons in the absence of an olfactory bulb.  |  Hayward, MD., et al. 2004. Brain Res Mol Brain Res. 132: 221-34. PMID: 15582160
4. Maturation of vomeronasal receptor neurons in vitro by coculture with accessory olfactory bulb neurons.  |  Moriya-Ito, K., et al. 2005. Chem Senses. 30: 111-9. PMID: 15703330
5. Delayed olfactory nerve regeneration in ApoE-deficient mice.  |  Nathan, BP., et al. 2005. Brain Res. 1041: 87-94. PMID: 15804503
6. Naris occlusion alters olfactory marker protein immunoreactivity in olfactory epithelium.  |  Waguespack, AM., et al. 2005. Brain Res. 1044: 1-7. PMID: 15862783
7. Olfactory marker protein modulates primary olfactory axon overshooting in the olfactory bulb.  |  St John, JA. and Key, B. 2005. J Comp Neurol. 488: 61-9. PMID: 15912500
8. Backbone dynamics of the olfactory marker protein as studied by 15N NMR relaxation measurements.  |  Gitti, RK., et al. 2005. Biochemistry. 44: 9673-9. PMID: 16008352
9. Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28.  |  Le, PN., et al. 2015. Pharmacol Ther. 146: 1-11. PMID: 25172549
10. The γ-OMP Algorithm for Feature Selection With Application to Gene Expression Data.  |  Tsagris, M., et al. 2022. IEEE/ACM Trans Comput Biol Bioinform. 19: 1214-1224. PMID: 33035156
11. Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing ferroptosis.  |  Li, R., et al. 2024. Toxicol Appl Pharmacol. 484: 116825. PMID: 38253083
12. Olfactory marker protein (OMP).  |  Margolis, FL. 1982. Scand J Immunol Suppl. 9: 181-99. PMID: 6963760
13. Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons.  |  Buiakova, OI., et al. 1996. Proc Natl Acad Sci U S A. 93: 9858-63. PMID: 8790421

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OMP Antibody (B-6) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-OMP Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OMP Antibody (B-6) Specifications

Alternate Product Name: OMP

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-163

Epitope Target: OMP

Epitope Species: human

Product Reactivity/Detection: OMP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for OMP Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin