Date published: 2026-1-21

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Omeprazole-d3 (CAS 922731-01-9)

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Alternate Names:
6-(Methoxy-d3)-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-be nzimidazole-4,5,7-d3; rac- Esomeprazole-d3; 6-(methoxy-d3)-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-Benzimidazole
Application:
Omeprazole-d3 is a labeled form of Omeprazole
CAS Number:
922731-01-9
Molecular Weight:
348.44
Molecular Formula:
C17H16D3N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Omeprazole-d3 is a deuterium-labeled version of omeprazole, primarily used in scientific research to investigate the compound′s metabolic pathway. The incorporation of deuterium atoms allows for detailed studies of the kinetics of omeprazole by providing a distinguishable mass difference that can be detected by mass spectrometry. Researchers use omeprazole-d3 to understand the metabolic stability of the parent compound and to study the isotope effects in chemical metabolism. It is also valuable in environmental fate studies where the deuterated compound provides insight into how omeprazole and its metabolites persist and degrade in various environments. Additionally, omeprazole-d3 serves as an internal standard in analytical chemistry to ensure the accuracy and precision of analytical methods used in the quantification of omeprazole in biological samples.


Omeprazole-d3 (CAS 922731-01-9) References

  1. Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study.  |  Flaherty, KT., et al. 2011. Cancer Chemother Pharmacol. 68: 1111-8. PMID: 21350850
  2. Internal standard tracked dilution to overcome challenges in dried blood spots and robotic sample preparation for liquid chromatography/tandem mass spectrometry assays.  |  Liu, G., et al. 2011. Rapid Commun Mass Spectrom. 25: 1250-6. PMID: 21488123
  3. Assessing orally bioavailable commercial silver nanoparticle product on human cytochrome P450 enzyme activity.  |  Munger, MA., et al. 2015. Nanotoxicology. 9: 474-81. PMID: 25137296
  4. Pharmacokinetic and pharmacodynamic effects of two omeprazole formulations on stomach pH and gastric ulcer scores.  |  Raidal, SL., et al. 2017. Equine Vet J. 49: 802-809. PMID: 28432741
  5. N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole.  |  Bachmann, F., et al. 2018. Eur J Pharm Sci. 120: 172-180. PMID: 29746911
  6. Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry.  |  Heo, JK., et al. 2018. Pharmaceutics. 10: PMID: 30004443
  7. An improved LC-MS/MS method for simultaneous evaluation of CYP2C9, CYP2C19, CYP2D6 and CYP3A4 activity.  |  Sreevatsav Adiraju, SK., et al. 2018. Bioanalysis. 10: 1577-1590. PMID: 30226084
  8. CSF omeprazole concentration and albumin quotient following high dose intravenous omeprazole in dogs.  |  Girod, M., et al. 2019. Res Vet Sci. 125: 266-271. PMID: 31326702
  9. Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study.  |  Jarmusch, AK., et al. 2020. Clin Transl Sci. 13: 972-984. PMID: 32216086
  10. Simultaneous enantioselective determination of omeprazole, rabeprazole, lansoprazole, and pantoprazole enantiomers in human plasma by chiral liquid chromatography-tandem mass spectrometry.  |  Sun, LN., et al. 2020. J Sep Sci. 43: 3183-3196. PMID: 32495501
  11. Intrauterine growth restriction alters the activity of drug metabolising enzymes in the maternal-placental-fetal unit.  |  McBride, GM., et al. 2021. Life Sci. 285: 120016. PMID: 34614415
  12. Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine.  |  Bachmann, F., et al. 2022. Br J Clin Pharmacol. 88: 1885-1896. PMID: 34648192
  13. Omeprazole Administration in Preterm Preeclampsia: a Randomized Controlled Trial to Study Its Effect on sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1), PlGF (Placental Growth Factor), and ET-1 (Endothelin-1).  |  Neuman, RI., et al. 2022. Hypertension. 79: 1297-1307. PMID: 35341328
  14. Maternal-placental-fetal drug metabolism is altered by late gestation undernutrition in the pregnant ewe.  |  Meakin, AS., et al. 2022. Life Sci. 298: 120521. PMID: 35367241

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Omeprazole-d3, 1 mg

sc-219485
1 mg
$350.00