ω-Agatoxin TK (CAS 158484-42-5)
See product citations (1)
QUICK LINKS
ω-Agatoxin TK is a peptide toxin found in the venom of the funnel-web spider Agelenopsis aperta and is known for its specificity in blocking P-type calcium channels. It is used in neurophysiological research to investigate the role of these channels in neurotransmitter release and neuronal excitability. By selectively inhibiting P-type channels, ω-Agatoxin TK allows scientists to study calcium dynamics in neurons and their influence on synaptic function. Research involving this toxin contributes to a deeper understanding of neurological disorders characterized by altered calcium channel function. Furthermore, it is used to delineate the distinct contributions of various types of calcium channels in brain function and to explore the potential for targeted interventions in the modulation of neuronal signaling.
ω-Agatoxin TK (CAS 158484-42-5) References
- Calcium influx is required for endocytotic membrane retrieval. | Vogel, SS., et al. 1999. Proc Natl Acad Sci U S A. 96: 5019-24. PMID: 10220411
- High-affinity inhibition of glutamate release from corticostriatal synapses by omega-agatoxin TK. | Barral, J., et al. 2001. Eur J Pharmacol. 430: 167-73. PMID: 11711028
- Somatostatin modulates Ca2+ currents in neostriatal neurons. | Vilchis, C., et al. 2002. Neuroscience. 109: 555-67. PMID: 11823066
- Phorbol ester stimulates a protein kinase C-mediated agatoxin-TK-sensitive calcium permeability pathway in human red blood cells. | Andrews, DA., et al. 2002. Blood. 100: 3392-9. PMID: 12384442
- Voltage-gated calcium channels in adult rat inferior colliculus neurons. | N'Gouemo, P. and Morad, M. 2003. Neuroscience. 120: 815-26. PMID: 12895521
- Omega-agatoxin-TK is a useful tool to study P-type Ca2+ channel-mediated changes in internal Ca2+ and glutamate release in depolarised brain nerve terminals. | Sitges, M. and Galindo, CA. 2005. Neurochem Int. 46: 53-60. PMID: 15567515
- Altered voltage-gated calcium channels in rat inferior colliculus neurons contribute to alcohol withdrawal seizures. | N'Gouemo, P. 2015. Eur Neuropsychopharmacol. 25: 1342-52. PMID: 25914156
- Presynaptic cannabinoid CB2 receptors modulate [3 H]-Glutamate release at subthalamo-nigral terminals of the rat. | Sánchez-Zavaleta, R., et al. 2018. Synapse. 72: e22061. PMID: 30022523
- Mechanistic ion channel interactions in red cells of patients with Gárdos channelopathy. | Jansen, J., et al. 2021. Blood Adv. 5: 3303-3308. PMID: 34468723
- Serotonin 5-HT1A and 5-HT1B receptor-mediated inhibition of glutamatergic transmission onto rat basal forebrain cholinergic neurones. | Nishijo, T., et al. 2022. J Physiol. 600: 3149-3167. PMID: 35598305
- Involvement of P-type calcium channels in high potassium-elicited release of neurotransmitters from rat brain slices. | Kimura, M., et al. 1995. Neuroscience. 66: 609-15. PMID: 7644024
- Omega-agatoxin-TK containing D-serine at position 46, but not synthetic omega-[L-Ser46]agatoxin-TK, exerts blockade of P-type calcium channels in cerebellar Purkinje neurons. | Kuwada, M., et al. 1994. Mol Pharmacol. 46: 587-93. PMID: 7969037
- Two types of calcium channels sensitive to omega-agatoxin- TK in cultured rat hippocampal neurones. | Teramoto, T., et al. 1995. Neuroreport. 6: 1684-8. PMID: 8527741
- A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons. | Teramoto, T., et al. 1997. Brain Res. 756: 225-30. PMID: 9187336
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ω-Agatoxin TK, 50 µg | sc-200190 | 50 µg | $250.00 | |||
ω-Agatoxin TK, 100 µg | sc-200190B | 100 µg | $500.00 | |||
ω-Agatoxin TK, 500 µg | sc-200190C | 500 µg | $1375.00 | |||
ω-Agatoxin TK, 1 mg | sc-200190D | 1 mg | $1725.00 |