Molecular structure of ω-Agatoxin IVA, CAS Number: 145017-83-0
ω-Agatoxin IVA (CAS 145017-83-0)
Application:
ω-Agatoxin IVA is a selective blocker of P-type voltage-dependent Ca channels
CAS Number:
145017-83-0
Purity:
≥90%
Molecular Weight:
5202.25
Molecular Formula:
C217H360N68O60S10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
This toxin is found in the venom of the funnel web spider, Agelenopsis aptera. It is a potent, selective blocker of mammalian P-type voltage-dependent calcium channels.
ω-Agatoxin IVA (CAS 145017-83-0) References
- P-type calcium channels blocked by the spider toxin omega-Aga-IVA. | Mintz, IM., et al. 1992. Nature. 355: 827-9. PMID: 1311418
- P-type calcium channels in rat central and peripheral neurons. | Mintz, IM., et al. 1992. Neuron. 9: 85-95. PMID: 1321648
- Calcium channels coupled to glutamate release identified by omega-Aga-IVA. | Turner, TJ., et al. 1992. Science. 258: 310-3. PMID: 1357749
- Differential responses to ω-agatoxin IVA in murine frontal cortex and spinal cord derived neuronal networks. | Knaack, GL., et al. 2013. Neurotoxicology. 37: 19-25. PMID: 23523780
- P/Q type (Cav2.1) Calcium Channel Blocker ω-Agatoxin IVA Alters Cleaved Caspase-3 and BDNF Expressions in the Rat Brain and Suppresses Seizure Activity. | Inan, SY., et al. 2024. Mol Neurobiol. 61: 1861-1872. PMID: 37798599
- Effect of omega-agatoxin-IVA on autonomic neurotransmission. | Lundy, PM. and Frew, R. 1994. Eur J Pharmacol. 261: 79-84. PMID: 8001657
- Synthesis of omega-agatoxin IVA and its related peptides. | Nishio, H., et al. 1993. Biochem Biophys Res Commun. 196: 1447-53. PMID: 8250902
- omega-agatoxin IVA and excitotoxicity in cortical neuronal cultures. | Lustig, HS., et al. 1996. Neurosci Lett. 213: 142-4. PMID: 8858628
- Dihydropyridine block of omega-agatoxin IVA- and omega-conotoxin GVIA-sensitive Ca2+ channels in rat pituitary melanotropic cells. | Mansvelder, HD., et al. 1996. Eur J Pharmacol. 311: 293-304. PMID: 8891612
- Omega-agatoxin IVA blocks spinal morphine/clonidine antinociceptive synergism. | Roerig, SC. and Howse, KM. 1996. Eur J Pharmacol. 314: 293-300. PMID: 8957249
- Effects of omega-agatoxin-IVA and omega-conotoxin-MVIIC on perineurial Ca++ and Ca(++)-activated K+ currents of mouse motor nerve terminals. | Xu, YF. and Atchison, WD. 1996. J Pharmacol Exp Ther. 279: 1229-36. PMID: 8968345
Inhibitor of:
B830028B13Rik, CAPS2, Cerebellin 1, Complexin-2, Complexin-3, Complexin-4, DOC2A, EF-HC1, FAM26A, KV1.1, Mas 7, Mover, MrgB4, N-type calcium channel α1B, neurexin II, Neurexophilin-4, Olfr571, P/Q-type Ca++ CP α1A, P/Q-type calcium channel α1A, PRRT2, R-type calcium channel α1E, Rim2, Synaptotagmin IV, Synaptotagmin V, Synaptotagmin VII, Synaptotagmin VIII, Synaptotagmin XII, Synaptotagmin XIII, Synaptotagmin XIV, UNC-13, UNC-80, Unc18-1, V3R 8, VCAC3, Vmn2r33, Vmn2r56, and Vmn2r80.Activator of:
Cacna2d3, N-type calcium channel α1B, P/Q-type calcium channel α1A, R-type Ca++ CP α1E, R-type calcium channel α1E, Synaptotagmin II, Synaptotagmin XI, Syntaxin, v-SNARE Vti1a, and VILIP-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ω-Agatoxin IVA, 100 µg | sc-302015 | 100 µg | $463.00 |