Molecular structure of Olvanil, CAS Number: 58493-49-5
Olvanil (CAS 58493-49-5)
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Application:
Olvanil is a TRPV1 agonist more potent than capsaicin
CAS Number:
58493-49-5
Purity:
≥98%
Molecular Weight:
417.6
Molecular Formula:
C26H43NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Olvanil is a potent agonist of the VR1 (TRPV1) receptor. Olvanil is described to be a 10-fold more potent agonist than Capsaicin (sc-3577) at the TRPV1. Also reported to act as a "hybrid" activator of CB1 receptor (CB1: Ki=1.6 muM CB2: Ki=15 muM) Olvanil is also demonstrated to block intracellular accumulation of Anandamide (sc-200790) through interaction with the anandamide transporter at concentrations similar to those needed for TRPV1 activation. Also inhibits FAAH (fatty acid amide hydrolase) (IC50=20muM).
Olvanil (CAS 58493-49-5) References
- The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons. | Szallasi, A., et al. 1999. Mol Pharmacol. 56: 581-7. PMID: 10462546
- Olvanil: more potent than capsaicin at stimulating the efferent function of sensory nerves. | Hughes, SR., et al. 1992. Eur J Pharmacol. 219: 481-4. PMID: 1425974
- Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors. | Kasckow, JW., et al. 2004. Prog Neuropsychopharmacol Biol Psychiatry. 28: 291-5. PMID: 14751425
- Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung. | Lee, MG., et al. 2005. Br J Pharmacol. 146: 596-603. PMID: 16056239
- Signaling mechanisms of down-regulation of voltage-activated Ca2+ channels by transient receptor potential vanilloid type 1 stimulation with olvanil in primary sensory neurons. | Wu, ZZ., et al. 2006. Neuroscience. 141: 407-19. PMID: 16678970
- Vanilloid (subtype 1) receptor-modulatory drugs inhibit [3H]batrachotoxinin-A 20-alpha-benzoate binding to Na+ channels. | Duan, Y., et al. 2007. Basic Clin Pharmacol Toxicol. 100: 91-5. PMID: 17244257
- TRPV1-mediated itch in seasonal allergic rhinitis. | Alenmyr, L., et al. 2009. Allergy. 64: 807-10. PMID: 19220220
- Olvanil: a non-pungent TRPV1 activator has anti-emetic properties in the ferret. | Chu, KM., et al. 2010. Neuropharmacology. 58: 383-91. PMID: 19825380
- Olvanil acts on transient receptor potential vanilloid channel 1 and cannabinoid receptors to modulate neuronal transmission in the trigeminovascular system. | Hoffmann, J., et al. 2012. Pain. 153: 2226-2232. PMID: 22902197
- Cross-linked enzyme aggregates of recombinant Candida antarctica lipase B for the efficient synthesis of olvanil, a nonpungent capsaicin analogue. | Diaz-Vidal, T., et al. 2019. Biotechnol Prog. 35: e2807. PMID: 30883025
- The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide. | Liu, L., et al. 1997. J Neurosci. 17: 4101-11. PMID: 9151727
- Interactions between synthetic vanilloids and the endogenous cannabinoid system. | Di Marzo, V., et al. 1998. FEBS Lett. 436: 449-54. PMID: 9801167
- Anandamide transport inhibition by the vanilloid agonist olvanil. | Beltramo, M. and Piomelli, D. 1999. Eur J Pharmacol. 364: 75-8. PMID: 9920187
Inhibitor of:
FAAH, and VR1.Activator of:
CB1, and VR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Olvanil, 5 mg | sc-201454 | 5 mg | $47.00 | |||
Olvanil, 25 mg | sc-201454A | 25 mg | $201.00 |