Molecular structure of Oltipraz, CAS Number: 64224-21-1
Oltipraz (CAS 64224-21-1)
Alternate Names:
4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione; RP 35972; NSC 347901; BRN 0978110
Application:
Oltipraz is an antischistosomiasis inhibitor of carcinogenesis
CAS Number:
64224-21-1
Purity:
≥98%
Molecular Weight:
226.34
Molecular Formula:
C8H6N2S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Oltipraz is a synthetic organosulfur compound that has been extensively studied in research focused on its ability to modulate various cellular pathways. In the context of biochemistry and molecular biology, Oltipraz is particularly researched for its role as a chemoprotective agent due to its capability to induce phase II detoxification enzymes. This induction is primarily mediated through the activation of the Nrf2-antioxidant response element (ARE) signaling pathway, which leads to the transcription of genes involved in the detoxification and elimination of reactive oxygen species and electrophiles. Researchers investigate the efficacy of Oltipraz in providing cytoprotection against diverse types of oxidative stresses. Additionally, studies examine the role of Oltipraz in the modulation of cellular apoptosis and its potential effects on cell proliferation. In environmental research, Oltipraz is used as a model compound to understand the impact of sulfides on various ecological processes.
Oltipraz (CAS 64224-21-1) References
- Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation. | Cho, IJ. and Kim, SG. 2003. J Biol Chem. 278: 44103-12. PMID: 12941938
- Mechanisms of chemoprotection by oltipraz. | Kensler, T., et al. 1992. J Cell Biochem Suppl. 16I: 167-72. PMID: 1305682
- The induction of CYP1A1 by oltipraz is mediated through calcium-dependent-calpain. | Dale, Y. and Eltom, SE. 2006. Toxicol Lett. 166: 150-9. PMID: 16891067
- Oltipraz may be useful in the prevention or treatment of Alzheimer's disease. | Gharibzadeh, S., et al. 2007. Med Hypotheses. 68: 915-6. PMID: 17222521
- Pharmacokinetic interaction between oltipraz and omeprazole in rats: Competitive inhibition of metabolism of oltipraz by omeprazole via CYP1A1 and 3A2, and of omeprazole by oltipraz via CYP1A1/2, 2D1/2, and 3A1/2. | Lee, DY., et al. 2007. Eur J Pharm Sci. 32: 328-39. PMID: 17935951
- Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation. | Cho, IJ., et al. 2009. Arch Pharm Res. 32: 625-35. PMID: 19407981
- Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1. | Kim, SG., et al. 2010. Clin Pharmacol Ther. 88: 360-8. PMID: 20664537
- Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. | Weerachayaphorn, J., et al. 2014. J Hepatol. 60: 160-6. PMID: 23978715
- Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response. | Tang, Y., et al. 2018. Eur Rev Med Pharmacol Sci. 22: 8918-8923. PMID: 30575935
- Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. | Zhang, Y., et al. 2021. J Appl Toxicol. 41: 2011-2020. PMID: 33959992
- Oltipraz ameliorates the progression of steatohepatitis in Nrf2-null mice fed a high-fat diet. | Kamisako, T. and Tanaka, Y. 2022. J Clin Biochem Nutr. 70: 147-153. PMID: 35400824
- Elucidating the Anti-Tumorigenic Efficacy of Oltipraz, a Dithiolethione, in Glioblastoma. | Kapoor-Narula, U. and Lenka, N. 2022. Cells. 11: PMID: 36231019
- Oltipraz, the activator of nuclear factor erythroid 2-related factor 2 (Nrf2), protects against the formation of BAPN-induced aneurysms and dissection of the thoracic aorta in mice by inhibiting activation of the ROS-mediated NLRP3 inflammasome. | Wang, D., et al. 2022. Eur J Pharmacol. 936: 175361. PMID: 36336010
- Oltipraz, a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) replication. | Prochaska, HJ., et al. 1995. J Cell Biochem Suppl. 22: 117-25. PMID: 8538188
Inhibitor of:
Aasdh, ADO, Aflatoxin B1, Aflatoxin B2, AKR7A3, AKR7A4, AKR7A5, ALDH1B1, Anamorsin, BPV E2, Cdt2, DPP3, EG637776, Gm648, Grx5, GSH-1, GST, GSTA2, GSTT4, HAGHL, HscB, KIAA0776, LGALS9, Ly6G6c, MAAI, MAGE-6, MGST1, NUBP1, OTTMUSG00000010546, OXNAD1, PA200, PADI2, psmd1 inhibitors, TRAF6, TXNDC14, and ZFP773.Activator of:
γ-GCSm, 4921501E09Rik, ABCF2, Aflatoxin B2, AKR1C13, AKR1E1, AKR7, AKR7A2, ALDH3A1, ALF, AMPKα2, ANT2, ASB-12, B020004J07Rik, C12orf48, C20orf195, C6orf85, carbonyl reductase 2, CD30L, CHCHD6, ChREBP, CLS1, CMBL, COMMD4, COX7a1, CT45-3, CYLD, CYP2B9, Cyp2c66, CYP2D40, CYP2J7, Cyp3a41b, DEC2, EG625716, EG669998, EMBP, FBXO7, Flipt1, FMO9, FUNDC2, Fv1, G6pd2, GAGE5, GGT6, Glutathione reductase, GSTA, Gsta1, GSTA3, GSTA4, GSTA5, GSTCD, GSTK1, GSTM1, GSTM4, GSTM5, GSTM7, GSTO1, GSTO2, GSTP1, Gstp2, GSTT1, GSTT2B, GSTT4, Keap1, LCE2B, LOC100039560, MafK, MARCH4, MGST3, MRP-S17, MRP2, MRP3, NAT-13, NF-E2, NKG2-D, Nrf2, Nrf3, p27, PEBP2αA, PGC-1α, PHF1, polycyclic aromatic hydrocarbons, Proteassemblin, PYGL, Reg lllα, SAA4, SP-C, Sptrx-1, SULT1A2, SULT1B1, THAP2, Thioguanine, TID-1, TMEM2, UGT1A1, UGT1A10, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B, UGT2B11, UGT2B37, USP5, ZBTB2, and ZNF439.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oltipraz, 500 mg | sc-205777 | 500 mg | $286.00 | |||
Oltipraz, 1 g | sc-205777A | 1 g | $622.00 |