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Oligomycin D (CAS 1404-59-7)

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Alternate Names:
Rutamycin; 26-Demethyloligomycin A
Application:
Oligomycin D is Oligomycin D (rutamycin) is an inhibitor of mitochondrial F1F0-ATPase
CAS Number:
1404-59-7
Molecular Weight:
777.04
Molecular Formula:
C44H72O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class. Oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.


Oligomycin D (CAS 1404-59-7) References

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  3. Purification and properties of the proton-translocating adenosine triphosphatase complex of bovine heart mitochondria.  |  Serrano, R., et al. 1976. J Biol Chem. 251: 2453-61. PMID: 177416
  4. ATP13, a nuclear gene of Saccharomyces cerevisiae essential for the expression of subunit 9 of the mitochondrial ATPase.  |  Ackerman, SH., et al. 1991. FEBS Lett. 278: 234-8. PMID: 1825065
  5. ATP10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex.  |  Ackerman, SH. and Tzagoloff, A. 1990. J Biol Chem. 265: 9952-9. PMID: 2141026
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  7. Mitochondrial signaling in Saccharomyces cerevisiae pseudohyphae formation induced by butanol.  |  Starovoytova, AN., et al. 2013. FEMS Yeast Res. 13: 367-74. PMID: 23448552
  8. [Construction of SPA7074-deficient mutant of biocontrol strain Streptomyces pactum Act12 and characterization of its secondary metabolites].  |  Duan, X., et al. 2016. Wei Sheng Wu Xue Bao. 56: 1883-91. PMID: 29741854
  9. The mitochondrial activation of sulfate and arsenate and their role in carcinogenesis.  |  Hadler, HI. and Cook, GL. 1979. J Environ Pathol Toxicol. 2: 601-12. PMID: 422926
  10. Cytoplasmically inherited respiratory deficiency of a mouse fibroblast line which is resistant to rutamycin.  |  Lichtor, T., et al. 1979. Biochemistry. 18: 2582-90. PMID: 444478
  11. Subunit interaction in the mitochondrial H+-translocating ATPase. The role of oligomycin sensitivity conferral protein and coupling factor 6 in ATPase binding and Pi-ATP exchange in mitochondrial membranes.  |  Liang, AM. and Fisher, RJ. 1983. J Biol Chem. 258: 4784-7. PMID: 6131898
  12. Energy-linked transhydrogenation from NADPH to [14C]NADP.  |  Hatefi, Y., et al. 1980. J Biol Chem. 255: 9526-9. PMID: 7430083
  13. Structure of the new spiroketal-macrolide A82548A.  |  Kirst, HA., et al. 1995. J Antibiot (Tokyo). 48: 990-6. PMID: 7592067
  14. Immunological properties of membrane-bound adenosine triphosphatase: immunological identification of rutamycin-sensitive F0.F1ATPase from Micrococcus luteus ATCC 4698 established by crossed immunoelectrophoresis.  |  Schmitt, M., et al. 1978. Biochim Biophys Acta. 509: 410-8. PMID: 77681
  15. Mitochondrial metabolism of pyruvate in bovine spermatozoa.  |  Hutson, SM., et al. 1977. J Biol Chem. 252: 1309-15. PMID: 838719

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Oligomycin D, 500 µg

sc-391526
500 µg
$332.00