Molecular structure of Oligomycin C, CAS Number: 11052-72-5
Oligomycin C (CAS 11052-72-5)
See product citations (6)
Alternate Names:
12-Deoxyoligomycin A
Application:
Oligomycin C is an ATP synthetase and RVD inhibitor
CAS Number:
11052-72-5
Purity:
>95%
Molecular Weight:
775.06
Molecular Formula:
C45H74O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Oligomycin C is part of a class of macrolide antibiotics and is a potent inhibitor of cell regulatory volume decrease (RVD). Oligomycin has been shown to inhibit ATP synthase by blocking the mitochondrial F1F0-ATPase. Doxorubicin-resistant HepG2 cell studies report that oligomycin can inhibit the activity of P-glycoprotein and induce apoptosis.
Oligomycin C (CAS 11052-72-5) References
- The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. | Fitch, ME., et al. 2000. Cell Death Differ. 7: 338-49. PMID: 10773818
- Mitochondria in eosinophils: functional role in apoptosis but not respiration. | Peachman, KK., et al. 2001. Proc Natl Acad Sci U S A. 98: 1717-22. PMID: 11172017
- Total synthesis of rutamycin B and oligomycin C. | Panek, JS. and Jain, NF. 2001. J Org Chem. 66: 2747-56. PMID: 11304197
- Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells. | Li, YC., et al. 2004. Chemotherapy. 50: 55-62. PMID: 15211078
- Volume-activated K+ and Cl- pathways of dissociated epithelial cells (MDCK): role of Ca2+. | Rothstein, A. and Mack, E. 1990. Am J Physiol. 258: C827-34. PMID: 1692191
- Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus. | Yang, PW., et al. 2010. Folia Microbiol (Praha). 55: 10-6. PMID: 20336498
- Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A. | Han, S., et al. 2015. Arch Biochem Biophys. 575: 1-7. PMID: 25849761
- Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue. | Han, S., et al. 2016. Mol Cells. 39: 211-6. PMID: 26883908
- Metabolomics of extracellular compounds and parasitic enzymes of Beauveria bassiana associated with biological control of whiteflies (Bemisia tabaci). | Bhadani, RV., et al. 2021. Pestic Biochem Physiol. 176: 104877. PMID: 34119221
- Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis. | Bilyk, O., et al. 2022. J Am Chem Soc. 144: 14555-14563. PMID: 35921248
- Ionic events during the volume response of human peripheral blood lymphocytes to hypotonic media. I. Distinctions between volume-activated Cl- and K+ conductance pathways. | Sarkadi, B., et al. 1984. J Gen Physiol. 83: 497-512. PMID: 6202824
- Volume regulation of Chinese hamster ovary cells in anisoosmotic media. | Sarkadi, B., et al. 1984. Biochim Biophys Acta. 774: 159-68. PMID: 6743652
- Biochemical characterization of a V-ATPase of tracheal smooth muscle plasma membrane fraction. | Pacheco, G., et al. 1996. Biochim Biophys Acta. 1282: 182-92. PMID: 8703972
Inhibitor of:
ATP5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oligomycin C, 1 mg | sc-202263 | 1 mg | $390.00 |