OLIG2 Antibody (H-10): sc-515947

OLIG2 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects OLIG2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-OLIG2 antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OLIG2 plays a crucial role in oligodendrocyte development, essential for forming myelin sheaths that insulate nerve fibers and facilitate efficient signal transmission in the nervous system. This function becomes particularly relevant in neurodegenerative diseases and demyelinating disorders, where OLIG2 expression shows notable changes. OLIG2 (H-10) antibody helps researchers study oligodendrogenesis regulation, as OLIG2 expression significantly increases in oligodendrogliomas, making OLIG2 a potential molecular marker for these brain tumors. OLIG2′s interactions with other proteins, such as Nkx-2.2, highlight its significance in neuronal patterning and cell fate determination during embryonic development. Using OLIG2 monoclonal antibody (H-10) enables researchers to explore oligodendrocyte development mechanisms and glial tumor pathogenesis, advancing therapeutic strategies for neurological conditions.

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OLIG2 Antibody (H-10) References:

1. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.  |  Briscoe, J., et al. 1999. Nature. 398: 622-7. PMID: 10217145
2. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors.  |  Zhou, Q., et al. 2000. Neuron. 25: 331-43. PMID: 10719889
3. Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.  |  Takebayashi, H., et al. 2000. Mech Dev. 99: 143-8. PMID: 11091082
4. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors.  |  Lu, QR., et al. 2001. Proc Natl Acad Sci U S A. 98: 10851-6. PMID: 11526205
5. Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube.  |  Sun, T., et al. 2001. Curr Biol. 11: 1413-20. PMID: 11566099
6. Novel small molecule inhibitors of the OLIG2 transcription factor: promising new therapeutics for glioblastoma.  |  Alton, G. and Kesari, S. 2016. Future Oncol. 12: 1001-4. PMID: 26867754
7. OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPsc-Based Organoid and Chimeric Mouse Models of Down Syndrome.  |  Xu, R., et al. 2019. Cell Stem Cell. 24: 908-926.e8. PMID: 31130512
8. Using the lineage determinants Olig2 and Sox10 to explore transcriptional regulation of oligodendrocyte development.  |  Sock, E. and Wegner, M. 2021. Dev Neurobiol. 81: 892-901. PMID: 34480425
9. Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain.  |  Tatsumi, K., et al. 2021. Mol Brain. 14: 163. PMID: 34749773
10. Preventing recurrence in Sonic Hedgehog Subgroup Medulloblastoma using the OLIG2 inhibitor CT-179.  |  Li, Y., et al. 2023. Res Sq.. PMID: 37333134
11. Implications of Olig2 silencing in oligodendrocyte precursor cells.  |  Fang, LP. and Bai, X. 2023. Neural Regen Res. 18: 2649-2650. PMID: 37449605
12. Antidepressant potential of total flavonoids from Astragalus in a chronic stress mouse model: Implications for myelination and Wnt/β-catenin/Olig2/Sox10 signaling axis modulation.  |  Tao, Y., et al. 2024. J Ethnopharmacol. 325: 117846. PMID: 38301982

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OLIG2 Antibody (H-10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-OLIG2 Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OLIG2 Antibody (H-10) Specifications

Alternate Product Name: Oligodendrocytes transcription factor 2

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 11-78

Epitope Target: OLIG2

Epitope Species: human

Product Reactivity/Detection: OLIG2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for OLIG2 Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin