Molecular structure of Oleyloxyethyl Phosphorylcholine, CAS Number: 96720-06-8
Oleyloxyethyl Phosphorylcholine (CAS 96720-06-8)
See product citations (6)
Application:
Oleyloxyethyl Phosphorylcholine is a potent inhibitor of PLA2
CAS Number:
96720-06-8
Purity:
≥98%
Molecular Weight:
477.7
Molecular Formula:
C25H52NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Oleyoxyethyl Phosphorylcholine is used as a potent inhibitor in order to investigate the various biological roles of phospholipase A2 (PLA2). Recent studies include using oleyoxyethyl phosphorylcholine as a PLA2 inhibitor in tobacco hornworm salivary glands which disrupted the hydrolysis of arachidonic acid. Oleyoxyethyl Phosphorylcholine may act to inhibit PLA2 ethanol-induced contraction of gastric smooth muscle and also reduced axonal outgrowth from the sciatic nerve stump. This compound is also found to inhibit the myogenic response of isolated renal arcuate arteries. In addition, oleyoxyethyl phosphorylcholine may be used to inhibit sPLA2.
Oleyloxyethyl Phosphorylcholine (CAS 96720-06-8) References
- Involvement of axonal phospholipase A2 activity in the outgrowth of adult mouse sensory axons in vitro. | Hornfelt, M., et al. 1999. Neuroscience. 91: 1539-47. PMID: 10391457
- Reactive oxygen species-induced aortic vasoconstriction and deterioration of functional integrity. | Peters, SL., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 361: 127-33. PMID: 10685867
- The involvement of phospholipase A(2) in ethanol-induced gastric muscle contraction. | Sim, SS., et al. 2001. Eur J Pharmacol. 413: 281-5. PMID: 11226404
- ATP-induced histamine release is in part related to phospholipase A2-mediated arachidonic acid metabolism in rat peritoneal mast cells. | Lee, YH., et al. 2001. Arch Pharm Res. 24: 552-6. PMID: 11794534
- Histamine release by hydrochloric acid is mediated via reactive oxygen species generation and phospholipase D in RBL-2H3 mast cells. | Kim, CJ., et al. 2002. Arch Pharm Res. 25: 675-80. PMID: 12433204
- Phospholipase A2 in salivary glands isolated from tobacco hornworms, Manduca sexta. | Tunaz, H. and Stanley, DW. 2004. Comp Biochem Physiol B Biochem Mol Biol. 139: 27-33. PMID: 15364285
- Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries. | Kauser, K., et al. 1991. Circ Res. 68: 1154-63. PMID: 1901255
- A borreliacidal factor in Amblyomma americanum saliva is associated with phospholipase A2 activity. | Zeidner, N., et al. 2009. Exp Parasitol. 121: 370-5. PMID: 19271281
- Stimulated bronchial epithelial cells release bioactive lysophosphatidylcholine 16:0, 18:0, and 18:1. | Zhuge, Y., et al. 2014. Allergy Asthma Immunol Res. 6: 66-74. PMID: 24404396
- A Biomimetic Nanoparticle to 'Lure and Kill' Phospholipase A2. | Zhang, Q., et al. 2020. Angew Chem Int Ed Engl. 59: 10461-10465. PMID: 32203634
- Regulation of free arachidonic acid levels in isolated salivary glands from the lone star tick: a role for dopamine. | Bowman, AS., et al. 1995. Arch Insect Biochem Physiol. 29: 309-27. PMID: 7655056
- Signaling pathways in the biphasic effect of angiotensin II on apical Na/H antiport activity in proximal tubule. | Houillier, P., et al. 1996. Kidney Int. 50: 1496-505. PMID: 8914015
- A specific prostaglandin E2 receptor and its role in modulating salivary secretion in the female tick, Amblyomma americanum (L.). | Qian, Y., et al. 1997. Insect Biochem Mol Biol. 27: 387-95. PMID: 9219365
Inhibitor of:
group IVB sPLA2, and sPLA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oleyloxyethyl Phosphorylcholine, 10 mg | sc-200711 | 10 mg | $78.00 | |||
Oleyloxyethyl Phosphorylcholine, 50 mg | sc-200711A | 50 mg | $277.00 |