Molecular structure of Oleoyl oxazolopyridine, CAS Number: 288862-58-8
Oleoyl oxazolopyridine (CAS 288862-58-8)
Application:
Oleoyl oxazolopyridine is a potent inhibitor of FAAH
CAS Number:
288862-58-8
Molecular Weight:
384.6
Molecular Formula:
C24H36N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Oleoyl oxazolopyridine is a potent inhibitor of fatty acid amide hydrolase (FAAH) (Ki = 1.3 nM and 2.3 nM for the rat and human enzymes, respectively). FAAH is the enzyme responsible for hydrolysis and inactivation of fatty acid amides, including anandamide and oleamide. Oleoyl oxazolopyridine is approximately 35-fold more potent than oleyl trifluoromethyl ketone when assayed under the same conditions. Selectivity of oleoyl oxazolopyridine for FAAH versus cannabinoid receptors or PLA2 has not been reported.
Oleoyl oxazolopyridine (CAS 288862-58-8) References
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- Cat iris sphincter smooth-muscle contraction: comparison of FP-class prostaglandin analog agonist activities. | Sharif, NA., et al. 2008. J Ocul Pharmacol Ther. 24: 152-63. PMID: 18355130
- Rat mast cells enhance fibroblast proliferation and fibroblast-populated collagen lattice contraction through gap junctional intercellular communications. | Foley, TT., et al. 2011. Plast Reconstr Surg. 127: 1478-1486. PMID: 21460656
- Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity. | Rakers, C., et al. 2012. Anal Biochem. 421: 699-705. PMID: 22146559
- Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol? | Jarzimski, C., et al. 2012. Br J Clin Pharmacol. 74: 54-9. PMID: 22242687
- Through gap junction communications, co-cultured mast cells and fibroblasts generate fibroblast activities allied with hypertrophic scarring. | Foley, TT. and Ehrlich, HP. 2013. Plast Reconstr Surg. 131: 1036-1044. PMID: 23629085
- Mast cells prevent dexamethasone-induced cell death of cultured fibroblasts: relationship to gap junctional intercellular communications. | Foley, TT. and Ehrlich, HP. 2014. Plast Reconstr Surg. 133: 638e-644e. PMID: 24776565
- Cross-validated stable-isotope dilution GC-MS and LC-MS/MS assays for monoacylglycerol lipase (MAGL) activity by measuring arachidonic acid released from the endocannabinoid 2-arachidonoyl glycerol. | Kayacelebi, AA., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1047: 151-159. PMID: 27511795
- Ethanolic extract of Streblus asper leaves protects against glutamate-induced toxicity in HT22 hippocampal neuronal cells and extends lifespan of Caenorhabditis elegans. | Prasansuklab, A., et al. 2017. BMC Complement Altern Med. 17: 551. PMID: 29282044
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oleoyl oxazolopyridine, 100 µg | sc-205418 | 100 µg | $36.00 | |||
Oleoyl oxazolopyridine, 500 µg | sc-205418A | 500 µg | $162.00 |