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Oleanonic Acid (CAS 17990-42-0)

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Alternate Names:
3-Oxoolean-12-en-28-oic Acid; 3-Ketooleanolic Acid; 3-Oxooleanolic acid
CAS Number:
17990-42-0
Molecular Weight:
454.68
Molecular Formula:
C30H46O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Oleanonic acid is a triterpenoid compound that has interest in various fields of research due to its unique structure and properties. In plant science, it is studied for its role in plant defense mechanisms and as a precursor in the biosynthesis of other biologically active triterpenoids. Chemists investigate oleanonic acid for its potential as a starting material in the synthesis of complex organic molecules, taking advantage of its rigid, polycyclic framework. The compound′s presence in certain plant species makes it a point of focus in botanical studies, particularly in relation to plants′ adaptive responses to environmental stressors. Additionally, oleanonic acid is utilized in material sciences, where researchers explore its incorporation into novel compounds with potential industrial applications, such as natural product-based catalysts and new materials with unique characteristics derived from its hydrophobicity and stability.


Oleanonic Acid (CAS 17990-42-0) References

  1. Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.  |  Giner-Larza, EM., et al. 2001. Eur J Pharmacol. 428: 137-43. PMID: 11779030
  2. Two new pentacyclic triterpenoids from Lantana camara LINN.  |  Begum, S., et al. 2008. Chem Pharm Bull (Tokyo). 56: 1317-20. PMID: 18758109
  3. Oxidation of oleanolic acid ofAvicennia officinalis leaves to oleanonic acid in the natural environment of Sunderban mangrove ecosystem.  |  Misra, S., et al. 1985. J Chem Ecol. 11: 339-42. PMID: 24309965
  4. Constituents of the roots and leaves of Ekebergia capensis and their potential antiplasmodial and cytotoxic activities.  |  Irungu, BN., et al. 2014. Molecules. 19: 14235-46. PMID: 25211004
  5. Nematicidal triterpenoids from Lantana camara.  |  Begum, S., et al. 2015. Chem Biodivers. 12: 1435-42. PMID: 26363887
  6. A simple and reliable analytical method based on HPLC-UV to determine oleanonic acid content in Chios gum mastic for quality control.  |  Jin, Y., et al. 2017. Arch Pharm Res. 40: 49-56. PMID: 27858280
  7. Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid.  |  Borkova, L., et al. 2017. ChemMedChem. 12: 390-398. PMID: 28084676
  8. Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: The role of PKCζ-NF-κB pathway.  |  Gao, H., et al. 2018. Mol Cell Endocrinol. 470: 259-268. PMID: 29138023
  9. Repeated dose (90 days) oral toxicity study of ursolic acid in Han-Wistar rats.  |  Geerlofs, L., et al. 2020. Toxicol Rep. 7: 610-623. PMID: 32435599
  10. Herb-drug interaction between Styrax and warfarin: Molecular basis and mechanism.  |  Zhang, F., et al. 2020. Phytomedicine. 77: 153287. PMID: 32739573
  11. wSDTNBI: a novel network-based inference method for virtual screening.  |  Wu, Z., et al. 2022. Chem Sci. 13: 1060-1079. PMID: 35211272
  12. Screening of Botanical Drugs against SARS-CoV-2 Entry Reveals Novel Therapeutic Agents to Treat COVID-19.  |  Cao, J., et al. 2022. Viruses. 14: PMID: 35215943
  13. Hypoglycaemic activity of Oleanonic acid, a 3-oxotriterpenoid isolated from Aidia Genipiflora (DC.) Dandy, involves inhibition of carbohydrate metabolic enzymes and promotion of glucose uptake.  |  Harley, BK., et al. 2022. Biomed Pharmacother. 149: 112833. PMID: 35316751
  14. Metabolite and Gene Expression Analysis Underlying Temporal and Spatial Accumulation of Pentacyclic Triterpenoids in Jujube.  |  Wen, C., et al. 2022. Genes (Basel). 13: PMID: 35627208
  15. Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs.  |  Hodoň, J., et al. 2022. Eur J Med Chem. 243: 114777. PMID: 36174412

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Oleanonic Acid, 250 mg

sc-478580
250 mg
$380.00