Oleandrin (CAS 465-16-7)
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Oleandrin is a cardenolide glycoside that is extensively researched in the field of plant secondary metabolites. This compound is found in the Nerium oleander plant and is of interest due to its interaction with the Na+/K+-ATPase ion pump, which plays a fundamental role in cellular electrolyte regulation. Researchers study oleandrin to understand its effects on ion transport across cell membranes, which is a critical process in maintaining cellular homeostasis. In addition to its role in basic plant physiology and biochemistry, oleandrin is also used in ecological studies, where it is examined for its impact on herbivory and plant defense mechanisms. The compound′s structural features provide a starting point for the synthesis of analogs used in fundamental research aimed at exploring the structure-activity relationship of similar natural products.
Oleandrin (CAS 465-16-7) References
- Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander. | Ni, D., et al. 2002. J Exp Ther Oncol. 2: 278-85. PMID: 12416031
- Oleandrin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 and potentiates apoptosis induced by ceramide. | Sreenivasan, Y., et al. 2003. Biochem Pharmacol. 66: 2223-39. PMID: 14609747
- Oleandrin: A cardiac glycosides with potent cytotoxicity. | Kumar, A., et al. 2013. Pharmacogn Rev. 7: 131-9. PMID: 24347921
- The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells. | Garofalo, S., et al. 2017. J Neurosci. 37: 3926-3939. PMID: 28292827
- Neuroprotective and tumoricidal activities of cardiac glycosides. Could oleandrin be a new weapon against stroke and glioblastoma? | Elmaci, İ., et al. 2018. Int J Neurosci. 128: 865-877. PMID: 29383986
- Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway. | Ko, YS., et al. 2018. Int J Mol Sci. 19: PMID: 30373171
- Determination of Oleandrin in Blood and Liver Samples by LC-MS/MS. | Zhai, JX., et al. 2018. Fa Yi Xue Za Zhi. 34: 585-589. PMID: 30896093
- Oleandrin induces apoptosis via activating endoplasmic reticulum stress in breast cancer cells. | Li, XX., et al. 2020. Biomed Pharmacother. 124: 109852. PMID: 31972357
- Oleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways. | Kanwal, N., et al. 2020. Food Chem Toxicol. 143: 111570. PMID: 32640345
- Negligible Oleandrin Content of Hot Dogs Cooked on Nerium oleander Skewers. | Suchard, J. and Greb, A. 2021. J Med Toxicol. 17: 57-60. PMID: 32803693
- Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer. | Li, X., et al. 2021. Cell Death Dis. 12: 314. PMID: 33762577
- Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology. | Zhai, J., et al. 2022. Front Pharmacol. 13: 822726. PMID: 35273501
- Antitumor effects of oleandrin in different types of cancers: Systematic review. | Francischini, CRD., et al. 2022. Toxicon. 216: 15-27. PMID: 35772506
- Glycoside oleandrin downregulates toll-like receptor pathway genes and associated miRNAs in human melanoma cells. | Eroğlu Güneş, C., et al. 2022. Gene. 843: 146805. PMID: 35964872
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oleandrin, 1 mg | sc-361972 | 1 mg | $229.00 |