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Olaparib (CAS 763113-22-0)

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Alternate Names:
Olaparib also known as 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine; 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone; AZD 2281; KU 0059436; KU 59436; 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine
Application:
Olaparib is a potent inhibitor of both PARP-1 and PARP-2 and is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition
CAS Number:
763113-22-0
Purity:
>99%
Molecular Weight:
434.47
Molecular Formula:
C24H23FN4O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Olaparib is a potent inhibitor of both PARP-1 and PARP-2, with IC50 = 5 nM and 1 nM, respectively. Olaparib is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition, which may result in the conversion of single-strand breaks to double-strand breaks during DNA replication, thus Olaparib has an effect on activating BRCA2-dependent recombination pathways. Olaparib may act to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo.


Olaparib (CAS 763113-22-0) References

  1. Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib.  |  Murai, J., et al. 2014. Mol Cancer Ther. 13: 433-43. PMID: 24356813
  2. The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 and BRCA2 mutant breast cancer cells.  |  Arun, B., et al. 2015. Int J Oncol. 47: 262-8. PMID: 25975349
  3. Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer.  |  Golan, T., et al. 2019. N Engl J Med. 381: 317-327. PMID: 31157963
  4. Olaparib Suppresses MDSC Recruitment via SDF1α/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice.  |  Sun, R., et al. 2021. Mol Ther. 29: 60-74. PMID: 33010818
  5. Olaparib-induced Apoptosis Through EBNA1-ATR-p38 MAPK Signaling Pathway in Epstein-Barr Virus-positive Gastric Cancer Cells.  |  Moon, SH., et al. 2022. Anticancer Res. 42: 555-563. PMID: 34969765
  6. Olaparib as maintenance treatment in patients with chemosensitive small cell lung cancer (STOMP): A randomised, double-blind, placebo-controlled phase II trial.  |  Woll, P., et al. 2022. Lung Cancer. 171: 26-33. PMID: 35872530

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Olaparib, 250 mg

sc-302017
250 mg
$206.00

Olaparib, 500 mg

sc-302017A
500 mg
$299.00

Olaparib, 1 g

sc-302017B
1 g
$485.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Olaparib, sc-302017, is a white or off-white solid.
Answered by: TechService7
Date published: 2017-02-15
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Rated 5 out of 5 by from Works well for cell culture and animal studiesWorks well for cell culture and animal studies.
Date published: 2015-06-08
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Olaparib | CAS 763113-22-0 is rated 5.0 out of 5 by 1.
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