Molecular structure of Olanzapine N-Oxide, CAS Number: 174794-02-6
Olanzapine N-Oxide (CAS 174794-02-6)
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Alternate Names:
2-methyl-4-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-thieno[3,2-c][1, 5]benzodiazepine
Application:
Olanzapine N-Oxide is a metabolite of Olanzapine
CAS Number:
174794-02-6
Molecular Weight:
328.43
Molecular Formula:
C17H20N4OS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Olanzapine N-Oxide is a chemical derivative of olanzapine, characterized by the addition of an oxygen atom to a nitrogen atom within the molecular structure of olanzapine. This N-oxidation changes some of the chemical and physical properties of the original molecule. Olanzapine N-Oxide is used in chemical research to study the properties and behavior of N-oxide compounds. This includes investigations into their stability, reactivity, and interactions with other chemical entities. In analytical chemistry, it can be used as a reference compound to develop and refine analytical methods, such as chromatography or spectroscopy, for the detection and quantification of similar compounds.
Olanzapine N-Oxide (CAS 174794-02-6) References
- Therapeutic drug monitoring data on olanzapine and its N-demethyl metabolite in the naturalistic clinical setting. | Skogh, E., et al. 2002. Ther Drug Monit. 24: 518-26. PMID: 12142637
- Heavy smoking, reduced olanzapine levels, and treatment effects: a case report. | Chiu, CC., et al. 2004. Ther Drug Monit. 26: 579-81. PMID: 15385843
- Valproate lowers plasma concentration of olanzapine. | Bergemann, N., et al. 2006. J Clin Psychopharmacol. 26: 432-4. PMID: 16855466
- Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors. | Nagashima, S., et al. 2009. Drug Metab Pharmacokinet. 24: 218-25. PMID: 19571433
- Data-dependent neutral gain MS3: toward automated identification of the N-oxide functional group in drug metabolites. | Habicht, SC., et al. 2010. J Am Soc Mass Spectrom. 21: 559-63. PMID: 20149682
- Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients. | Söderberg, MM., et al. 2013. Pharmacogenomics J. 13: 544-50. PMID: 23147717
- Determination of olanzapine and N-desmethyl-olanzapine in plasma using a reversed-phase HPLC coupled with coulochemical detection: correlation of olanzapine or N-desmethyl-olanzapine concentration with metabolic parameters. | Lu, ML., et al. 2013. PLoS One. 8: e65719. PMID: 23741510
- Postmortem redistribution of olanzapine following intramuscular administration of olanzapine pamoate in dogs. | Johnson, JT., et al. 2015. Forensic Sci Int. 257: 353-358. PMID: 26517823
- Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3. | Okubo, M., et al. 2016. Hum Psychopharmacol. 31: 83-92. PMID: 26856397
- A sensitive capillary LC-UV method for the simultaneous analysis of olanzapine, chlorpromazine and their FMO-mediated N-oxidation products in brain microdialysates. | Hendrickx, S., et al. 2017. Talanta. 162: 268-277. PMID: 27837829
- Quantification of olanzapine and its three metabolites by liquid chromatography-tandem mass spectrometry in human body fluids obtained from four deceased, and confirmation of the reduction from olanzapine N-oxide to olanzapine in whole blood in vitro. | Nozawa, H., et al. 2023. Forensic Toxicol.. PMID: 36997675
- Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine. | Ring, BJ., et al. 1996. J Pharmacol Exp Ther. 276: 658-66. PMID: 8632334
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Olanzapine N-Oxide, 2.5 mg | sc-208130 | 2.5 mg | $393.00 |