Okadaic Acid, Potassium Salt (CAS 155751-72-7)
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Okadaic Acid, Potassium Salt is a water-soluble analog of Okadaic Acid. The compound is a potent inhibitor of serine/threonine-specific protein phosphatases PP1, PP2A, 5534, PP2C and endogenous phosphatase smooth muscle myosin at IC50 of 10-15 nM, 0.1 nM, 5 muM, >10 muM and 15-70 nM respectively. This inhibition action has been used to stimulate the activity of glucose transport and has been observed to block insulin′s stimulation of glucose transport by inhibiting IRS-1 phosphorylation. Okadaic Acid, Potassium Salt has been used as a response modifier in the study of large granular lymphocyte and T-cell biochemistry. In addition to inhibitive activities it is a tumor promoter and has been used to study nitric oxide metabolism, apoptosis, cell cycle and calcium signaling. Okadaic Acid, Potassium Salt is an activator of PKC lambda and PKC zeta.
Okadaic Acid, Potassium Salt (CAS 155751-72-7) References
- Reversible activation of glutamate transport in rat brain glia by protein kinase C and an okadaic acid-sensitive phosphoprotein phosphatase. | Daniels, KK. and Vickroy, TW. 1999. Neurochem Res. 24: 1017-25. PMID: 10478941
- Okadaic acid: a new probe for the study of cellular regulation. | Cohen, P., et al. 1990. Trends Biochem Sci. 15: 98-102. PMID: 2158158
- Stimulation of glucose transport and glucose transporter phosphorylation by okadaic acid in rat adipocytes. | Lawrence, JC., et al. 1990. J Biol Chem. 265: 19768-76. PMID: 2174052
- Development of an efficient protein phosphatase-based colorimetric test for okadaic acid detection. | Sassolas, A., et al. 2011. Anal Chim Acta. 702: 262-8. PMID: 21839207
- Automated flow-through amperometric immunosensor for highly sensitive and on-line detection of okadaic acid in mussel sample. | Dominguez, RB., et al. 2012. Talanta. 99: 232-7. PMID: 22967546
- Okadaic acid: a rapid inducer of lamellar bodies in small intestinal enterocytes. | Danielsen, EM., et al. 2014. Toxicon. 88: 77-87. PMID: 24951872
- Inhibitory effect of a toxin okadaic acid, isolated from the black sponge on smooth muscle and platelets. | Karaki, H., et al. 1989. Br J Pharmacol. 98: 590-6. PMID: 2555015
- Antibody-based donor-acceptor spatial reconfiguration in decorated lanthanide-doped nanoparticle colloids for the quantification of okadaic acid biotoxin. | Stipić, F., et al. 2015. Colloids Surf B Biointerfaces. 135: 481-489. PMID: 26283497
- Self-assembled monolayer-based immunoassays for okadaic acid detection in seawater as monitoring tools. | Leonardo, S., et al. 2018. Mar Environ Res. 133: 6-14. PMID: 29174400
- Study of ceramic membrane behavior for okadaic acid and heavy-metal determination in filtered seawater. | Pérez, L., et al. 2019. J Environ Manage. 232: 564-573. PMID: 30508776
- Activation of peripheral large granular lymphocytes with the serine/threonine phosphatase inhibitor, okadaic acid. | McVicar, DW., et al. 1994. Eur J Immunol. 24: 165-70. PMID: 8020552
- Role of protein phosphorylation in TNF-induced apoptosis: phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U937 variants. | Wright, SC., et al. 1993. J Cell Biochem. 53: 222-33. PMID: 8263039
- Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity. | Jullien, D., et al. 1993. J Biol Chem. 268: 15246-51. PMID: 8392070
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Okadaic Acid, Potassium Salt, 50 µg | sc-202261 | 50 µg | $136.00 |