Molecular structure of OBAA, CAS Number: 134531-42-3
OBAA (CAS 134531-42-3)
See product citations (3)
Application:
OBAA is a potent inhibitor of phospholipase A2
CAS Number:
134531-42-3
Purity:
98%
Molecular Weight:
428.6
Molecular Formula:
C28H44O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
OBAA (3-(4-Octadecyl)-benzoylacrylic acid) is a potent inhibitor and therefore useful experimental tool for PLA2 (phospholipase A2). OBAA specifically displayed ability to inhibit PLA2 from snake venom, but not from porcine pancreas. OBAA was observed in experiments to inhibit Na+ concentration increase induced by thapsigargin and blocks Ca2+entry into pathogenic Tyrpanosoma brucei. It has also been shown to induce apoptosis in human umbilical vein endothelial cells (HUVEC) and inhibit arachidonic acid release.
OBAA (CAS 134531-42-3) References
- Beta1-integrins mediate Ca2+-signalling and T cell spreading via divergent pathways. | Schöttelndreier, H., et al. 1999. Cell Signal. 11: 611-9. PMID: 10433522
- Phospholipase A(2) is involved in thapsigargin-induced sodium influx in human lymphocytes. | Nofer, JR., et al. 2000. Arch Biochem Biophys. 374: 213-21. PMID: 10666300
- The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C. | Bastianetto, S., et al. 2000. J Neurochem. 74: 2268-77. PMID: 10820186
- Roles for nitric oxide and arachidonic acid in the induction of heterosynaptic cerebellar LTD. | Reynolds, T. and Hartell, NA. 2001. Neuroreport. 12: 133-6. PMID: 11201073
- Regulation of pharyngeal motility by FMRFamide and related peptides in the medicinal leech, Hirudo medicinalis. | O'Gara, BA., et al. Invert Neurosci. 4: 41-53. PMID: 12491073
- Distinct receptors and different transduction mechanisms for ATP and adenosine at the frog motor nerve endings. | Sokolova, E., et al. 2003. Eur J Neurosci. 18: 1254-64. PMID: 12956724
- Phospholipase A2 inhibition by alkylbenzoylacrylic acids. | Köhler, T., et al. 1992. Biochem Pharmacol. 44: 805-13. PMID: 1324685
- Quantum dot-NBD-liposome luminescent probes for monitoring phospholipase A2 activity. | Kethineedi, VR., et al. 2013. Anal Bioanal Chem. 405: 9729-37. PMID: 24173659
- The role of arachidonic acid/cyclooxygenase cascade, phosphodiesterase IV and Rho-kinase in H2S-induced relaxation in the mouse corpus cavernosum. | Aydinoglu, F. and Ogulener, N. 2017. Pharmacol Rep. 69: 610-615. PMID: 28501682
- Assessment of the Oxidative Potential and Oxidative Burden from Occupational Exposures to Particulate Matter. | Fleck, ADS., et al. 2022. Ann Work Expo Health. 66: 379-391. PMID: 34595509
- Phospholipase A2 activation is not required for long-term synaptic depression. | Stanton, PK. 1995. Eur J Pharmacol. 273: R7-9. PMID: 7737325
- Inhibitors of phospholipase promote apoptosis of human endothelial cells. | Miao, JY., et al. 1997. J Biochem. 121: 612-8. PMID: 9133633
- Phospholipase A2 is not responsible for lysophosphatidylcholine-induced damage in cardiomyocytes. | Chen, M., et al. 1998. Am J Physiol. 275: H1782-7. PMID: 9815086
- Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid. | Eintracht, J., et al. 1998. Biochem J. 336 (Pt 3): 659-66. PMID: 9841878
Inhibitor of:
group V PLA2, and PLA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OBAA, 5 mg | sc-202748 | 5 mg | $98.00 |