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OAC-1 is an Oct-4 activator which enhances and accelerates iPSC reprogramming in the presence of 4F (Oct-4, Sox-2, c-Myc and GKLF) by ~20-fold (relative to 4F by itself). OAC-1 upregulates mRNA expression of Oct-4, Sox-2 and Nanog, as well as Tet1. It has shown no effects, however, on the p53-p21 pathway or Wnt-β-catenin signaling.
1. Li, Wendong., et al., 2012. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proceedings of the National Academy of Sciences of the United States of America. 109(51): 20853-8. PMID: 23213213
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