O6-(2-Hydroxypropyl)-2′-deoxyguanosine (CAS 1327339-22-9)

O6-(2-Hydroxypropyl)-2′-deoxyguanosine (OHPdG) is a significant DNA adduct resulting from the reaction between 1,2-epoxy-3-butene (EB) and deoxyguanosine (dG) within DNA. It serves as a reliable biomarker, indicating exposure to EB, which is prevalent in tobacco smoke, automobile exhaust, and industrial emissions. Extensive research has focused on O6-(2-Hydroxypropyl)-2′-deoxyguanosine as a biomarker to assess exposure to EB. Its presence has been detected in diverse tissues and bodily fluids of both humans and animals exposed to EB. O6-(2-Hydroxypropyl)-2′-deoxyguanosine has been instrumental in evaluating EB′s carcinogenic potential and measuring the effectiveness of interventions aimed at reducing EB exposure. Furthermore, it has played a significant role in exploring the metabolism and distribution of EB in humans and animals. O6-(2-Hydroxypropyl)-2′-deoxyguanosine acts as a mutagenic DNA adduct, inducing base substitutions and frameshift mutations during DNA replication. Additionally, it hinders DNA repair processes by inhibiting the activity of DNA repair enzymes. Furthermore, it produces mutagenic and genotoxic effects and triggers oxidative stress and inflammation in vitro. While O6-(2-Hydroxypropyl)-2′-deoxyguanosine can be repaired through the base excision repair pathway, the repair efficiency remains low, leading to persistent adducts within DNA for extended periods.