Molecular structure of o-Toluidine hydrochloride, CAS Number: 636-21-5
o-Toluidine hydrochloride (CAS 636-21-5)
Alternate Names:
2-Methylaniline hydrochloride
CAS Number:
636-21-5
Molecular Weight:
143.61
Molecular Formula:
C7H9N•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
o-Toluidine hydrochloride is a compound with surfactant properties. It finds application in the production of food hydrocolloids and in the treatment of wastewater. Notably, this product exhibits genotoxic effects, likely attributed to its capacity to interact with DNA and form p-hydroxybenzoic acid. Research indicates that o-Toluidine hydrochloride shares similar pharmacokinetic properties with other surfactants. While the exact mechanism of genotoxicity remains unknown, it could be attributed to the presence of nitrogen atoms within the molecule or its interaction with DNA.
o-Toluidine hydrochloride (CAS 636-21-5) References
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- NTP Comparative Toxicity and Carcinogenicity Studies of o-Nitrotoluene and o-Toluidine Hydrochloride (CAS Nos. 88-72-2 and 636-21-5) Administered in Feed to Male F344/N Rats. | Elwell, M. 1996. Toxic Rep Ser. 44: 1-C8. PMID: 12118263
- Bioassay of o-toluidine hydrochloride for possible carcinogenicity. | ,. 1979. Natl Cancer Inst Carcinog Tech Rep Ser. 153: 1-147. PMID: 12799709
- [Production of 5,7-disulfonamido-1,2,4-benzothiodiazine-1,1-dioxide and chlorosulfonation of o-toluidine hydrochloride and acethyl derivatives]. | BINIECKI, S., et al. 1962. Acta Pol Pharm. 19: 257-61. PMID: 13869286
- Tuning the structure of SDS micelles by substituted anilinium ions. | Garg, G., et al. 2005. J Phys Chem B. 109: 1340-6. PMID: 16851101
- An interlaboratory evaluation of the Syrian hamster embryo cell transformation assay using eighteen coded chemicals. | Jones, CA., et al. 1988. Toxicol In Vitro. 2: 103-16. PMID: 20702344
- Establishing a total allowable concentration of o-toluidine in drinking water incorporating early lifestage exposure and susceptibility. | English, JC., et al. 2012. Regul Toxicol Pharmacol. 64: 269-84. PMID: 22940434
- Assays of three carcinogen/non-carcinogen chemical pairs for in vivo induction of chromosome aberrations, sister chromatid exchanges and micronuclei. | McFee, AF., et al. 1989. Environ Mol Mutagen. 14: 207-20. PMID: 2583129
- Distinct differences in the mechanisms of mucosal damage and γ-H2AX formation in the rat urinary bladder treated with o-toluidine and o-anisidine. | Toyoda, T., et al. 2019. Arch Toxicol. 93: 753-762. PMID: 30656379
- Colorimetric method for estimation of carbaryl and its residues on grains. | Rangaswamy, JR. and Majumder, SK. 1974. J Assoc Off Anal Chem. 57: 592-4. PMID: 4208709
- Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4'-sulfonyldianiline, or D & C red No. 9. | Goodman, DG., et al. 1984. J Natl Cancer Inst. 73: 265-73. PMID: 6588231
- Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats. | Hecht, SS., et al. 1982. Cancer Lett. 16: 103-8. PMID: 7116337
- Metabolism of o-[methyl-14C]toluidine in the F344 rat. | Son, OS., et al. 1980. Xenobiotica. 10: 457-68. PMID: 7445517
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
o-Toluidine hydrochloride, 5 g | sc-250597 | 5 g | $130.00 | |||
o-Toluidine hydrochloride, 25 g | sc-250597A | 25 g | $250.00 |