o,p′-DDT (CAS 789-02-6)
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o,p′-DDT (ortho-para DDT) is one of the isomers of DDT (dichlorodiphenyltrichloroethane), a synthetic chemical compound once widely used as an insecticide. The o,p′-DDT isomer refers to the positioning of chlorine atoms on the benzene rings at the ortho and para positions. This specific isomer is less commonly used and less effective as an insecticide compared to the more prevalent p,p′-DDT isomer, which has both chlorine atoms in the para positions. DDT is a chemical compound that functions as a pesticide and insecticide. It acts by disrupting the nervous system of insects, leading to paralysis and ultimately death. This compound targets the voltage-gated sodium channels in the nerve cells of insects, leading to prolonged depolarization and inhibition of repolarization. This compound′s role in experimental applications involves studying its effects on insect populations and understanding its mechanism of action at the molecular and cellular levels.
o,p′-DDT (CAS 789-02-6) References
- Reductive metabolism of p,p'-DDT and o,p'-DDT by rat liver cytochrome P450. | Kitamura, S., et al. 2002. Drug Metab Dispos. 30: 113-8. PMID: 11792678
- Effects of o,p'-DDT on the 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in murine Hepa-1c1c7 cells. | Jeong, HG. and Kim, JY. 2002. Food Chem Toxicol. 40: 1685-92. PMID: 12176094
- o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver. | Kiyosawa, N., et al. 2008. Toxicol Sci. 101: 350-63. PMID: 17984292
- Using the o,p'-DDT/p,p'-DDT ratio to identify DDT sources in China. | Qiu, X. and Zhu, T. 2010. Chemosphere. 81: 1033-8. PMID: 20851452
- Interference of xenoestrogen o,p'-DDT on the action of endogenous estrogens at environmentally realistic concentrations. | Zhong, L., et al. 2013. Bull Environ Contam Toxicol. 90: 591-5. PMID: 23478948
- o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats. | Kwekel, JC., et al. 2013. Toxicol Appl Pharmacol. 273: 532-41. PMID: 24096037
- Associations of maternal o,p'-DDT and p,p'-DDE levels with birth outcomes in a Bolivian cohort. | Arrebola, JP., et al. 2016. Environ Res. 151: 469-477. PMID: 27567351
- Enantio-selective molecular dynamics of (±)-o,p-DDT uptake and degradation in water-sediment system. | Ali, I., et al. 2018. Environ Res. 160: 353-357. PMID: 29055210
- Comparative thyroid disruption by o,p'-DDT and p,p'-DDE in zebrafish embryos/larvae. | Wu, L., et al. 2019. Aquat Toxicol. 216: 105280. PMID: 31518776
- Preparation and Characterization of Aptamers Against O,p'-DDT. | Zhang, W., et al. 2020. Int J Mol Sci. 21: PMID: 32210057
- Expression of estrogen-, progesterone-, and androgen-responsive genes in MCF-7 and MDA-MB-231 cells treated with o,p'-DDT, p,p'-DDT, or endosulfan. | Kalinina, TS., et al. 2021. J Biochem Mol Toxicol. 35: 1-8. PMID: 33728745
- Influence of o,p'-DDT on MUC5AC expression via regulation of NF-κB/AP-1 activation in human lung epithelial cells. | Lee, GH., et al. 2021. J Toxicol Environ Health A. 84: 836-845. PMID: 34167450
- Behaviors and trophodynamics of o,p'-dichlorodiphenyltrichloroethane (o,p'-DDT) in the aquatic food web: Comparison with p,p'-DDT. | Sun, J., et al. 2022. Sci Total Environ. 821: 153447. PMID: 35092765
- Quercetin protects human liver cells from o,p'-DDT-induced toxicity by suppressing Nrf2 and NADPH oxidase-regulated ROS production. | Liu, X. and Song, L. 2022. Food Chem Toxicol. 161: 112849. PMID: 35122929
- o,p'-DDT and its metabolites inhibit progesterone-dependent responses in yeast and human cells. | Klotz, DM., et al. 1997. Mol Cell Endocrinol. 129: 63-71. PMID: 9175630
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
o,p′-DDT, 50 mg | sc-257937 | 50 mg | $193.00 |