o,p′-DDE (CAS 3424-82-6)
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The synthetic compound o,p′-DDE serves as a model substance in laboratory experiments, enabling the exploration of organochlorine impacts on biological systems. As an organochlorine compound, it combines chlorine and carbon atoms and plays a vital role in various products, including insecticides, herbicides, and flame retardants. Numerous studies have extensively examined o,p′-DDE′s effects on diverse biological systems. Researchers utilize o,p′-DDE in laboratory applications to investigate its influence on the endocrine, reproductive, and immune systems. Moreover, its role in cancer and disease development is also a subject of inquiry. o,p′-DDE′s impact on the environment, particularly aquatic, terrestrial, and soil organisms, has been a key focus. Acting as an endocrine disruptor, o,p′-DDE binds to the androgen receptor, hampering the interaction between androgens like testosterone and their target tissues. This interference can disrupt the harmonious functioning of hormones within the body.
o,p′-DDE (CAS 3424-82-6) References
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- Effects of o,p'-DDE, heptachlor, and 17beta-estradiol on vitellogenin gene expression and the growth hormone/insulin-like growth factor-I axis in the tilapia, Oreochromis mossambicus. | Davis, LK., et al. 2009. Comp Biochem Physiol C Toxicol Pharmacol. 149: 507-14. PMID: 19101654
- Determination of octanol-air partition coefficients and supercooled liquid vapor pressures of organochlorine pesticides. | Zhang, N., et al. 2009. J Environ Sci Health B. 44: 649-56. PMID: 20183074
- Plasma concentrations of o,p'DDD, o,p'DDA, and o,p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: results of a retrospective ENS@T multicenter study. | Hermsen, IG., et al. 2011. J Clin Endocrinol Metab. 96: 1844-51. PMID: 21470991
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- Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1. | Truong, KM., et al. 2019. Toxicol Sci. 170: 509-524. PMID: 31127943
- Autophagy-related neurotoxicity is mediated via AHR and CAR in mouse neurons exposed to DDE. | Wnuk, A., et al. 2020. Sci Total Environ. 742: 140599. PMID: 32721735
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- Effects of o,p'-DDE, a Mitotane Metabolite, in an Adrenocortical Carcinoma Cell Line. | Bach, C., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 36558937
- Validation of a Modified QuEChERS Method for the Determination of Selected Organochlorine Compounds in Honey. | Lewiński, R., et al. 2023. Molecules. 28: PMID: 36677901
- Comparison of p-p'-DDE and o-p'-DDE on eggshell thickness and Ca binding activity of shell gland in ducks. | Lundholm, CE. 1980. Acta Pharmacol Toxicol (Copenh). 47: 377-84. PMID: 7293792
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
o,p′-DDE, 50 mg | sc-257936 | 50 mg | $364.00 |