Molecular structure of o-Phenanthroline monohydrate, CAS Number: 5144-89-8
o-Phenanthroline monohydrate (CAS 5144-89-8)
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Alternate Names:
1,10-Phenanthroline
Application:
o-Phenanthroline monohydrate is a chelating agent for Fe2+
CAS Number:
5144-89-8
Purity:
≥99%
Molecular Weight:
198.22
Molecular Formula:
C12H8N2•H2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a general matrix metalloproteinase inhibitor. Forms a red chelate with ferrous (iron II, Fe++) ion that absorbs maximally at 510 nm. Has been employed as a photometric reagent for iron. The product forms a complex with Fe++, but not with Fe+++. NH2OH can be added to the solution to reduce the Fe+++ to Fe++ for analysis of iron. Due to the compound′s strong UV absorbance, it may interfere with spectrophotometric assays. When complexed with copper, it possesses nuclease activity that has been employed in studying DNA-protein interactions.
o-Phenanthroline monohydrate (CAS 5144-89-8) References
- Shedding of membrane type 1 matrix metalloproteinase in a human breast carcinoma cell line. | Harayama, T., et al. 1999. Jpn J Cancer Res. 90: 942-50. PMID: 10551322
- Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. | Wang, Y., et al. 1999. J Biol Chem. 274: 33043-9. PMID: 10551873
- The effect of 1,10-phenanthroline on the chromosome damage and sister-chromatid exchanges induced by streptozotocin in mammalian and insect cells. | Bolzán, AD., et al. 2000. Mutat Res. 447: 221-6. PMID: 10751605
- Proteolysis of AA amyloid fibril proteins by matrix metalloproteinases-1, -2, and -3. | Stix, B., et al. 2001. Am J Pathol. 159: 561-70. PMID: 11485914
- Iron contamination in adenosine triphosphate: a warning. | McCarty, RE. 1992. Anal Biochem. 205: 371-2. PMID: 1443587
- Nuclease activity of 1,10-phenanthroline-copper in study of protein-DNA interactions. | Sigman, DS., et al. 1991. Methods Enzymol. 208: 414-33. PMID: 1779842
- 1,10-Phenanthroline derivatives as mediators for glucose oxidase. | Oztekin, Y., et al. 2010. Biosens Bioelectron. 26: 267-70. PMID: 20605713
- Transition metal complexes and radical anion salts of 1,10-phenanthroline derivatives annulated with a 1,2,5-tiadiazole and 1,2,5-tiadiazole 1,1-dioxide moiety: multidimensional crystal structures and various magnetic properties. | Shuku, Y. and Awaga, K. 2014. Molecules. 19: 609-40. PMID: 24402196
- The Antibacterial Activity of Metal Complexes Containing 1,10- phenanthroline: Potential as Alternative Therapeutics in the Era of Antibiotic Resistance. | Viganor, L., et al. 2017. Curr Top Med Chem. 17: 1280-1302. PMID: 27697043
- Structural analysis of metal chelation of the metalloproteinase thermolysin by 1,10-phenanthroline. | Nam, KH. 2021. J Inorg Biochem. 215: 111319. PMID: 33310458
- Novel cytotoxic 1,10-phenanthroline-triterpenoid amphiphiles with supramolecular characteristics capable of coordinating 64Cu(II) labels. | Bildziukevich, U., et al. 2022. Org Biomol Chem. 20: 8157-8163. PMID: 36222062
- Glioma invasion in vitro: regulation by matrix metalloprotease-2 and protein kinase C. | Uhm, JH., et al. 1996. Clin Exp Metastasis. 14: 421-33. PMID: 8871536
- Different collagenase gene products have different roles in degradation of type I collagen. | Krane, SM., et al. 1996. J Biol Chem. 271: 28509-15. PMID: 8910479
Inhibitor of:
α2ML1, carboxypeptidase B2 (TAFI), Enzyme, ISCA2, LEPREL4, Meprin A alpha, MMP, OTTMUSG00000013284, OTTMUSG00000014862, OTTMUSG00000015220, OTTMUSG00000015279, OTTMUSG00000015337, OTTMUSG00000015417, OTTMUSG00000015643, OTTMUSG00000015752, TMLH, TRIM64B, TRIM79, TrpRS, ZIM1, and ZIM2.Activator of:
ADAM18, and Myelin P2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
o-Phenanthroline monohydrate, 1 g | sc-202256 | 1 g | $43.00 | |||
o-Phenanthroline monohydrate, 25 g | sc-202256A | 25 g | $188.00 |