Molecular structure of O-Methylsterigmatocystin, CAS Number: 17878-69-2
O-Methylsterigmatocystin (CAS 17878-69-2)
Application:
O-Methylsterigmatocystin is an agent structurally related to the aflatoxins
CAS Number:
17878-69-2
Purity:
>95%
Molecular Weight:
338.3
Molecular Formula:
C19H14O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
O-Methylsterigmatocystin is a mycotoxin that functions as a potent inhibitor of protein synthesis. It exerts its mechanism of action by binding to the 60S ribosomal subunit, thereby preventing the formation of peptide bonds during translation. This interference with protein synthesis ultimately leads to the disruption of cellular processes and can induce cytotoxic effects in various experimental models. O-Methylsterigmatocystin may exhibit genotoxic properties, causing DNA damage and potentially contributing to mutagenesis.
O-Methylsterigmatocystin (CAS 17878-69-2) References
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- Thin-layer chromatographic separation of sterigmatocystin, 5-methoxy-sterigmatocystin and O-methylsterigmatocystin. | Sullivan, G., et al. 1976. J Chromatogr. 116: 490-2. PMID: 1245589
- Kinetics of the oxidoreductase involved in the conversion of O-methylsterigmatocystin to aflatoxin B1. | Gengan, RM., et al. 2006. Prep Biochem Biotechnol. 36: 297-306. PMID: 16971301
- Conversion of 11-hydroxy-O-methylsterigmatocystin to aflatoxin G1 in Aspergillus parasiticus. | Zeng, H., et al. 2011. Appl Microbiol Biotechnol. 90: 635-50. PMID: 21153813
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- Mycotoxins from the Fungus Botryotrichum piluliferum. | Rajachan, OA., et al. 2017. J Agric Food Chem. 65: 1337-1341. PMID: 28135416
- Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus. | Bhatnagar, D., et al. 1987. Appl Environ Microbiol. 53: 1028-33. PMID: 3111363
- Fate of the methyl group during the conversion of sterigmatocystin into O-methylsterigmatocystin and aflatoxin B1 by cell-free preparations of Aspergillus parasiticus. | Bhatnagar, D. and Cleveland, TE. 1988. Biochimie. 70: 743-7. PMID: 3139090
- Formation of B- and M-group aflatoxins and precursors by Aspergillus flavus on maize and its implication for food safety. | Schamann, A., et al. 2022. Mycotoxin Res. 38: 79-92. PMID: 35288866
- The production of chaetoglobosins, sterigmatocystin, O-methylsterigmatocystin, and chaetocin by Chaetomium spp. and related fungi. | Udagawa, S., et al. 1979. Can J Microbiol. 25: 170-7. PMID: 436014
- The conversion of sterigmatocystin to O-methylsterigmatocystin and aflatoxin B1 by a cell-free preparation. | Jeenah, MS. and Dutton, MF. 1983. Biochem Biophys Res Commun. 116: 1114-8. PMID: 6418171
- Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis. | Yu, J., et al. 1993. Appl Environ Microbiol. 59: 3564-71. PMID: 8285664
- ord1, an oxidoreductase gene responsible for conversion of O-methylsterigmatocystin to aflatoxin in Aspergillus flavus. | Prieto, R. and Woloshuk, CP. 1997. Appl Environ Microbiol. 63: 1661-6. PMID: 9143099
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O-Methylsterigmatocystin, 1 mg | sc-202254 | 1 mg | $120.00 |