Molecular structure of O-Desmorpholinopropyl Gefitinib, CAS Number: 184475-71-6
O-Desmorpholinopropyl Gefitinib (CAS 184475-71-6)
Alternate Names:
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
CAS Number:
184475-71-6
Molecular Weight:
319.72
Molecular Formula:
C15H11ClFN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
O-Desmorpholinopropyl Gefitinib is a metabolite of Gefitinib, which is a potent inhibitor of tyrosine phosporylation in EGFR. The chemical structure of O-Desmorpholinopropyl Gefitinib consists of a quinazolin-6-ol core with a phenylamino group attached to a chloro-fluoro-phenyl ring, enabling it to interact with multiple biological targets. It is involved in the inhibition of enzymes such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).
O-Desmorpholinopropyl Gefitinib (CAS 184475-71-6) References
- Discovery of EGFR-Targeted Environment-Sensitive fluorescent probes for cell imaging and efficient tumor detection. | Wang, LX., et al. 2022. Bioorg Chem. 121: 105585. PMID: 35183859
- Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer. | Abdelmalek, CM., et al. 2022. J Med Chem. 65: 4616-4632. PMID: 35286086
- Computational prediction for the metabolism of human UDP-glucuronosyltransferase 1A1 substrates. | Luo, YB., et al. 2022. Comput Biol Med. 149: 105959. PMID: 36063691
- Switching from ultrafast electron transfer to proton transfer in excited drug-protein complexes upon biotransformation. | Tamarit, L., et al. 2022. Chem Sci. 13: 9644-9654. PMID: 36091919
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O-Desmorpholinopropyl Gefitinib, 1 g | sc-212456 | 1 g | $347.00 |