Molecular structure of O-Desmethyltramadol HCl, CAS Number: 73986-53-5
O-Desmethyltramadol HCl (CAS 73986-53-5)
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Application:
O-Desmethyltramadol HCl is a metabolite of tramadol
CAS Number:
73986-53-5
Purity:
≥98%
Molecular Weight:
285.81
Molecular Formula:
C15H23NO2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
O-Desmethyltramadol HCl exhibits potent kinase inhibitory properties, targeting enzymes critical for cellular signaling and metabolism. This compound serves as an analgesic agent. It is also a principal active metabolite derived from tramadol.
O-Desmethyltramadol HCl (CAS 73986-53-5) References
- Glucuronidation of racemic O-desmethyltramadol, the active metabolite of tramadol. | Lehtonen, P., et al. 2010. Eur J Pharm Sci. 41: 523-30. PMID: 20797434
- Kratom alkaloids and O-desmethyltramadol in urine of a 'Krypton' herbal mixture consumer. | Arndt, T., et al. 2011. Forensic Sci Int. 208: 47-52. PMID: 21112167
- Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton. | Kronstrand, R., et al. 2011. J Anal Toxicol. 35: 242-7. PMID: 21513619
- Pharmacokinetics of tramadol and metabolites O-desmethyltramadol and N-desmethyltramadol in adult horses. | Stewart, AJ., et al. 2011. Am J Vet Res. 72: 967-74. PMID: 21728858
- Enantioselective analysis of unbound tramadol, O-desmethyltramadol and N-desmethyltramadol in plasma by ultrafiltration and LC-MS/MS: application to clinical pharmacokinetics. | de Moraes, NV., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 880: 140-7. PMID: 22173007
- Postmortem redistribution of tramadol and O-desmethyltramadol. | Costa, I., et al. 2013. J Anal Toxicol. 37: 670-5. PMID: 24084873
- On the sulfation of O-desmethyltramadol by human cytosolic sulfotransferases. | Rasool, MI., et al. 2017. Pharmacol Rep. 69: 953-958. PMID: 28802998
- Inhibition by O-desmethyltramadol of glutamatergic excitatory transmission in adult rat spinal substantia gelatinosa neurons. | Koga, A., et al. 2019. Mol Pain. 15: 1744806918824243. PMID: 30799694
- Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. | Lee, J., et al. 2019. Drug Des Devel Ther. 13: 1751-1761. PMID: 31213765
- Intrinsic clearance rate of O-desmethyltramadol (M1) by glucuronide conjugation and phase I metabolism by feline, canine and common brush-tailed possum microsomes. | Izes, AM., et al. 2020. Xenobiotica. 50: 776-782. PMID: 31755346
- Automated high-throughput analysis of tramadol and O-desmethyltramadol in dried blood spots. | Luginbühl, M., et al. 2020. Drug Test Anal. 12: 1126-1134. PMID: 32396691
- Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling. | Al-Qurain, AA., et al. 2021. J Pharm Biomed Anal. 203: 114171. PMID: 34087551
- Physiologically Based Pharmacokinetic Modeling to Assess the Impact of CYP2D6-Mediated Drug-Drug Interactions on Tramadol and O-Desmethyltramadol Exposures via Allosteric and Competitive Inhibition. | Long, T., et al. 2022. J Clin Pharmacol. 62: 76-86. PMID: 34383318
- Intoxication by 3-MeO-PCP and O-desmethyltramadol: an unusual NPS mix. | Castro, AL., et al. 2022. Int J Legal Med. 136: 1297-1301. PMID: 35359189
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O-Desmethyltramadol HCl, 5 mg | sc-301496 | 5 mg | $1078.00 |