O-3M3FBS (CAS 313981-55-4)
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O-3M3FBS is a synthetic small molecule known primarily as a potent and irreversible activator of phospholipase C (PLC), an enzyme involved in intracellular signal transduction pathways. In research applications, O-3M3FBS is utilized to study the PLC signaling pathway, which plays a role in various cellular processes such as cell growth, differentiation, and motility. By activating PLC, researchers can mimic the effects of physiological agonists and investigate the downstream effects of increased inositol trisphosphate and diacylglycerol levels, which are second messengers that modulate calcium release and protein kinase C activation, respectively. This compound aids in elucidating the complex cellular responses to external stimuli and contributes to the understanding of how disruptions in PLC activity can influence various biological outcomes. Additionally, O-3M3FBS is used in probing the interaction between PLC and other signaling proteins, thereby shedding light on the intricate networks that govern cellular responses.
O-3M3FBS (CAS 313981-55-4) References
- Identification of a compound that directly stimulates phospholipase C activity. | Bae, YS., et al. 2003. Mol Pharmacol. 63: 1043-50. PMID: 12695532
- Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. | Krjukova, J., et al. 2004. Br J Pharmacol. 143: 3-7. PMID: 15302681
- The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. | Lee, YN., et al. 2005. Cancer Lett. 222: 227-35. PMID: 15863272
- Acetylcholine-induced Ca2+ oscillations are modulated by a Ca2+ regulation of InsP3R2 in rat portal vein myocytes. | Fritz, N., et al. 2008. Pflugers Arch. 456: 277-83. PMID: 18026983
- The novel phospholipase C activator, m-3M3FBS, induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling. | Jung, EM., et al. 2008. Apoptosis. 13: 133-45. PMID: 18060503
- Phospholipase C-independent effects of 3M3FBS in murine colon. | Dwyer, L., et al. 2010. Eur J Pharmacol. 628: 187-94. PMID: 19931239
- Cholesterol modulates ion channels via down-regulation of phosphatidylinositol 4,5-bisphosphate. | Chun, YS., et al. 2010. J Neurochem. 112: 1286-94. PMID: 20015154
- Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate. | Buchmayer, F., et al. 2013. Proc Natl Acad Sci U S A. 110: 11642-7. PMID: 23798435
- Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors. | Semple-Rowland, S., et al. 2013. PLoS One. 8: e83378. PMID: 24386190
- Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons. | Szebenyi, SA., et al. 2014. Front Cell Neurosci. 8: 336. PMID: 25374507
- Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors. | Wilke, BU., et al. 2014. Nat Commun. 5: 5540. PMID: 25420509
- A Closely Associated Phospholipase C Regulates Cation Channel Function through Phosphoinositide Hydrolysis. | Sturgeon, RM. and Magoski, NS. 2018. J Neurosci. 38: 7622-7634. PMID: 30037836
- Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux. | Luethi, D., et al. 2022. Commun Biol. 5: 1259. PMID: 36396757
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O-3M3FBS, 10 mg | sc-204142 | 10 mg | $143.00 | |||
O-3M3FBS, 50 mg | sc-204142A | 50 mg | $469.00 |