O-1918 (CAS 536697-79-7)
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O-1918 is a chemical compound known for its role as a selective antagonist of the putative cannabinoid receptor GPR18. In research applications, O-1918 is used to elucidate the functions of GPR18 and to distinguish its activity from that of the classical cannabinoid receptors CB1 and CB2. Studies involving O-1918 are for understanding the endocannabinoid system, particularly in the context of how GPR18 contributes to physiological processes like inflammation, pain sensation, and intraocular pressure regulation. By blocking GPR18, researchers can investigate the receptor′s involvement in cellular signaling pathways and its potential as a target for the discovery of new bioactive compounds. Furthermore, the use of O-1918 helps to clarify the profile of novel endocannabinoid-like compounds and their interactions within the broader network of cannabinoid receptors.
O-1918 (CAS 536697-79-7) References
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- A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats. | Zakrzeska, A., et al. 2010. Br J Pharmacol. 160: 574-84. PMID: 20105178
- Role of Endothelium in Abnormal Cannabidiol-Induced Vasoactivity in Retinal Arterioles. | Su, EN., et al. 2015. Invest Ophthalmol Vis Sci. 56: 4029-37. PMID: 26098470
- Mechanisms of vasorelaxation induced by the cannabidiol analogue compound O-1602 in the rat small mesenteric artery. | Al Suleimani, YM., et al. 2015. Eur J Pharmacol. 765: 107-14. PMID: 26297305
- Inhibition of GPR 55 improves dysregulated immune response in experimental sepsis. | Zhou, J., et al. 2018. Clin Hemorheol Microcirc. 70: 553-561. PMID: 30347614
- Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity. | Simcocks, AC., et al. 2019. Endocr Connect. 8: 203-216. PMID: 30707678
- The Role of Atypical Cannabinoid Ligands O-1602 and O-1918 on Skeletal Muscle Homeostasis with a Focus on Obesity. | Simcocks, AC., et al. 2020. Int J Mol Sci. 21: PMID: 32824681
- Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS. | Perna, E., et al. 2021. Gut. 70: 1275-1286. PMID: 33023902
- Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918. | Stott, LA., et al. 2021. Heliyon. 7: e07201. PMID: 34189291
- GPR18-Mediated Relaxation of Human Isolated Pulmonary Arteries. | Kozłowska, H., et al. 2022. Int J Mol Sci. 23: PMID: 35163351
- The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice. | Bardin, M., et al. 2022. Biochem Pharmacol. 201: 115075. PMID: 35525326
- WIN55212-2 Modulates Intracellular Calcium via CB1 Receptor-Dependent and Independent Mechanisms in Neuroblastoma Cells. | Pulgar, VM., et al. 2022. Cells. 11: PMID: 36230909
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O-1918, 1 mg | sc-202746 | 1 mg | $61.00 | |||
O-1918, 5 mg | sc-202746A | 5 mg | $235.00 |