NUFIP1 Antibody (2662C1a): sc-81567

NUFIP1 Antibody (2662C1a) is a mouse monoclonal IgG1 antibody that detects NUFIP1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-NUFIP1 antibody (2662C1a) is available as a non-conjugated format. NUFIP1, or Nuclear fragile X mental retardation-interacting protein 1, is a 495 amino acid protein primarily localized in the nucleus, where NUFIP1 plays a crucial role in neuronal development and function. NUFIP1 is known to interact with FMR1, the fragile X mental retardation protein, which is essential for the maturation of dendritic spines, and BRCA1, a well-known tumor suppressor involved in breast and ovarian cancer. The interaction between NUFIP1 and FMR1 facilitates the transport of specific messenger ribonucleoprotein particles (mRNPs) to active neuronal synapses, thereby regulating the translation of mRNAs associated with synaptic plasticity. Additionally, when NUFIP1 associates with BRCA1, NUFIP1 forms a complex that binds to the positive elongation factor P-TEFb, enhancing RNA polymerase II transcription and contributing to the expression of tumor suppressor genes. The presence of a C2H2-type zinc finger in NUFIP1 suggests a role in protein-DNA interactions, further emphasizing NUFIP1′s importance in gene regulation. NUFIP1 is expressed throughout the body, highlighting NUFIP1′s potential involvement in various cellular processes beyond neuronal function.

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NUFIP1 Antibody (2662C1a) References:

1. A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.  |  Bardoni, B., et al. 1999. Hum Mol Genet. 8: 2557-66. PMID: 10556305
2. Assignment of NUFIP1 (nuclear FMRP interacting protein 1) gene to chromosome 13q14 and assignment of a pseudogene to chromosome 6q12.  |  Bardoni, B., et al. 2000. Cytogenet Cell Genet. 89: 11-3. PMID: 10894927
3. NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes.  |  Bardoni, B., et al. 2003. Exp Cell Res. 289: 95-107. PMID: 12941608
4. BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.  |  Cabart, P., et al. 2004. Oncogene. 23: 5316-29. PMID: 15107825
5. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly.  |  McKeegan, KS., et al. 2007. Mol Cell Biol. 27: 6782-93. PMID: 17636026

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NUFIP1 Antibody (2662C1a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-NUFIP1 Antibody (2662C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NUFIP1 Antibody (2662C1a) Specifications

Alternate Product Name: NUFIP1

Product Clone Name: 2662C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: NUFIP1

Epitope Species: human

Product Reactivity/Detection: NUFIP1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for NUFIP1 Antibody (2662C1a): N/A