nucleoporin p62 Antibody (E-4): sc-48389

nucleoporin p62 Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects nucleoporin p62 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-nucleoporin p62 antibody (E-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. nucleoporin p62 plays a crucial role in the nuclear transport system, facilitating selective movement of proteins and RNA across the nuclear envelope. Located within the nuclear pore complex, nucleoporin p62 is essential for importing proteins into the nucleus and exporting newly synthesized mRNA, ensuring proper cellular function and gene expression regulation. nucleoporin p62 interaction with other proteins, such as karyopherin α and karyopherin β, is vital for recognition and docking of substrates destined for nuclear import. Additionally, nucleoporin p62 interacts with nuclear transport factor 2 (NTF2), which is important for functional integrity. nucleoporin p62 ability to mediate these processes underscores its significance in maintaining cellular homeostasis and responding to various physiological signals.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

nucleoporin p62 Antibody (E-4) References:

1. Immunohistochemical study of nucleoporin p62 in the hippocampus and hypothalamus of the rat brain.  |  Xie, CX., et al. 2000. Neuroreport. 11: 2965-7. PMID: 11006975
2. Nucleoporin p62 antibodies in a case of mixed connective tissue disease.  |  Kraemer, DM., et al. 2003. Clin Diagn Lab Immunol. 10: 329-31. PMID: 12626463
3. The N-terminal domain of the mammalian nucleoporin p62 interacts with other nucleoporins of the FXFG family during interphase.  |  Stochaj, U., et al. 2006. Exp Cell Res. 312: 2490-9. PMID: 16730000
4. Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity.  |  Béaslas, O., et al. 2012. Exp Cell Res. 318: 1933-45. PMID: 22683860
5. Detection of Autoantibodies Against Nucleoporin p62 in Sera of Patients With Primary Biliary Cholangitis.  |  Bauer, A. and Habior, A. 2019. Ann Lab Med. 39: 291-298. PMID: 30623621
6. Direct interaction of nucleoporin p62 with mRNA during its export from the nucleus.  |  Dargemont, C., et al. 1995. J Cell Sci. 108 (Pt 1): 257-63. PMID: 7738103
7. Role of different domains in the self-association of rat nucleoporin p62.  |  Buss, F., et al. 1994. J Cell Sci. 107 (Pt 2): 631-8. PMID: 8207085
8. Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis.  |  Wesierska-Gadek, J., et al. 1996. Gastroenterology. 110: 840-7. PMID: 8608894
9. Sequence analysis of a nuclear pore complex protein in a lower metazoan: nucleoporin p62 of the coelenterate Hydra vulgaris.  |  Fischer, R., et al. 1997. Gene. 195: 285-93. PMID: 9305774
10. The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62.  |  Yoshima, T., et al. 1997. Biochem Biophys Res Commun. 240: 228-33. PMID: 9367915

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-nucleoporin p62 Antibody (E-4) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-nucleoporin p62 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

nucleoporin p62 Antibody (E-4) Specifications

Alternate Product Name: NUP62

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 401-522

Epitope Target: nucleoporin p62

Epitope Species: human

Product Reactivity/Detection: nucleoporin p62

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for nucleoporin p62 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred nucleoporin p62 antibody is nucleoporin p62 Antibody (C-9): sc-48373.