nucleoporin p62 Antibody (2A11): sc-101543
- nucleoporin p62 Antibody (2A11) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against amino acids 1-300 of nucleoporin p62 of human origin
- recommended for detection of amino acids 1-179 of nucleoporin p62 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for nucleoporin p62 Antibody (2A11). This work is in progress.
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Nucleoporin p62 Antibody (2A11) is a rat monoclonal IgG1 antibody that detects nucleoporin p62 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nucleoporin p62 plays a crucial role in the nuclear transport system, acting as a key component of the nuclear pore complex that facilitates the selective transport of proteins and RNA between the nucleus and cytoplasm. Nucleoporin p62′s strategic location within the nuclear envelope allows interaction with various transport factors, including karyopherin α and karyopherin β, which are essential for recognizing and docking import substrates. Additionally, nucleoporin p62 is involved in the export of nascent mRNA strands, highlighting dual functionality in both import and export processes. Proper functioning of nucleoporin p62 is vital for maintaining cellular homeostasis, as disruptions in nuclear transport can lead to various diseases, including cancer and neurodegenerative disorders. Anti-nucleoporin p62 antibody (2A11) serves as an invaluable tool for researchers studying the intricacies of nuclear transport and its implications in health and disease.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
nucleoporin p62 Antibody (2A11) References:
- PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. | Geisler, S., et al. 2010. Nat Cell Biol. 12: 119-31. PMID: 20098416
- Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. | Ichimura, Y., et al. 2013. Mol Cell. 51: 618-31. PMID: 24011591
- TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. | Pan, JA., et al. 2016. Mol Cell. 61: 720-733. PMID: 26942676
- SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. | Salazar, G., et al. 2020. Autophagy. 16: 1092-1110. PMID: 31441382
- Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates. | Peng, SZ., et al. 2021. Nat Commun. 12: 5989. PMID: 34645818
- Palmitoylation restricts SQSTM1/p62-mediated autophagic degradation of NOD2 to modulate inflammation. | Zhou, L., et al. 2022. Cell Death Differ. 29: 1541-1551. PMID: 35066577
- The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62. | Linares, JF., et al. 2022. Cell Rep. 39: 110792. PMID: 35545049
- Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication. | Tan, X., et al. 2023. Cell Rep. 42: 112286. PMID: 36952345
- Suppression of USP8 sensitizes cells to ferroptosis via SQSTM1/p62-mediated ferritinophagy. | Liu, L., et al. 2023. Protein Cell. 14: 230-234. PMID: 37051673
- LLPS of SQSTM1/p62 and NBR1 as outcomes of lysosomal stress response limits cancer cell metastasis. | Noguchi, T., et al. 2023. Proc Natl Acad Sci U S A. 120: e2311282120. PMID: 37847732
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
nucleoporin p62 Antibody (2A11) | sc-101543 | 200 µg/ml | $322.00 |